US6096509: Apparatus and method for compound profiling of living cells
Inventor(s):
Okun; Ilya , San Diego, CA
Okun; Alex , San Diego, CA
Applicant(s):
Axiom Biotechnologies, Inc., San Diego, CA
Issued/Filed Dates:
Aug. 1, 2000 / May 24, 1999
Application Number:
US1999000317793
Abstract:
An apparatus and method for real-time measurement of a cellular
response of a test compound or series of test compounds (303) on a
flowing suspension of cells (349), in which a homogeneous
suspension of each member of a series of cell types (349) is
combined with a concentration of a test compound (303), directed
through a detection zone (355), and a cellular response of the living
cells is measured in real time as the cells in the test mixture are
flowing through the detection zone (355). The apparatus may be used
in automated screening of libraries of compounds, and is capable of
real-time variation of concentrations of test and standard compounds
and generation of dose/response profiles within a short timespan. |
