Finally listening to the conference call. There is specific
reference to both the diabetes (TLK 17411) and caspase-3 projects. Just parking....
<TABLE>
<CAPTION>
Product Development Commercialization
Candidate Clinical Indication Status Rights
- ---------------------------------------------------------------------------------------------------
<S> <C> <C> <C>
Cancer
TLK286 Chemotherapy-resistant Phase I Worldwide
Targeted cancers, including . phase I clinical
chemotherapeutic drug colon, ovarian, lung, trial commenced
pancreas, 1/00
lymphoma/leukemia and
breast
TLK199 Chemotherapy-induced low Pre-IND Worldwide
Bone marrow stimulant white blood cell count, . IND-enabling
or neutropenia studies initiated
6/99
. clinical grade material
prepared 1/00
IGF-1 inhibitor Prostate cancer Lead optimization Worldwide
. small
molecule
inhibitors
discovered
- ---------------------------------------------------------------------------------------------------
Diabetes
Insulin-independent Type 2 diabetes Candidate nomination/lead Worldwide except
insulin receptor optimization Japan and most other
Asian countries
activators . oral activity in animal
models
. preclinical and safety
assessment initiated
Insulin-dependent Type 2 diabetes Candidate nomination/lead Worldwide except
insulin receptor optimization Japan and most other
activators Asian countries
. activity in animal models
. preclinical and safety
assessment initiated
- ---------------------------------------------------------------------------------------------------
Inflammatory disease
MCP-1 antagonist Rheumatoid arthritis, Lead optimization North and South
asthma atherosclerosis, . small America and jointly
multiple sclerosis, molecule in Europe
cancer inhibitors
discovered
. activity in animal models
MIP-1 alpha inhibitor Rheumatoid arthritis, Lead optimization North and South
multiple sclerosis, . small America and jointly
cancer molecule in Europe
inhibitors
discovered
IL-8 inhibitor Rheumatoid arthritis, Lead optimization North and South
nephritis, psoriasis, . small America and jointly
cancer molecule in Europe
inhibitors
discovered
- ---------------------------------------------------------------------------------------------------
Stroke
Caspase-3 inhibitor Stroke Lead optimization Worldwide
. small
molecule
inhibitors
discovered
</TABLE> |
