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Biotech / Medical : Trickle Portfolio

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To: tuck who wrote (309)	12/31/2000 5:35:59 PM
From: Pseudo Biologist	Read Replies (2) of 1784

four-stranded beta-barrel topology; beta-sandwich architecture; steered Langevin dynamics Tuck, your link did not work for me, but I am guessing it points to a version of this abstract by Klimov & Thirumalai: ncbi.nlm.nih.gov (or something close to it). If so, then the full PNAS article is available free online: pnas.org Figure 1 has a schematic picture of the topology/architecture of the proteins studied in this work. As for "steered Langevin dynamics," this is a biased (steered) version of a technique the tries to impose some amount of random noise and viscosity over the trajectory (dynamics) of a system, in this case a protein unfolding or folding. The cool thing here is that this kind of stuff can be done in real life (not just in silico as in the paper); meaning stretching out individual protein molecules. Here is a free link to a mini-review of such work: jbc.org Last, while I find Thirumalai's work interesting, I do think the man on this line of work ought to be UCSF's Ken Dill (awfully nice guy as well): ucsf.edu Happy New Year and thanks for all your efforts, PB

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