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Pastimes : Clown-Free Zone... sorry, no clowns allowed
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To: Mark Adams who wrote (61614)1/25/2001 1:16:51 PM
From: flatsville  Read Replies (2) of 436258
 
Mark--

It works like this:

In addition to showing that a protein can multiply and cause disease without help from nucleic acids, we have gained insight into how scrapie PrP propagates in cells. Many details remain to be worked out, but one aspect appears quite clear: the main difference between normal PrP and scrapie PrP is conformational. Evidently, the scrapie protein propagates itself by contacting normal PrP molecules and somehow causing them to unfold and Bip from their usual conformation to the scrapie shape. This change initiates a cascade in which newly converted molecules change the shape of other normal PrP molecules, and so on. These events apparently occur on a membrane in the cell interior.

sciam.com

Did you ever read Kurt Vonnegut's Cat's Cradle?...Think Ice Nine.
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