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Biotech / Medical : Biotech Valuation
CRSP 51.08+0.7%11:41 AM EST

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To: Jibacoa who wrote (2716)1/29/2001 8:00:10 PM
From: aknahow  Read Replies (3) of 52153
 
Any information, pro or con on Onyx Pharmaceutical (onxx) would be appreciated. I am specifically interested in what anyone know about the drug discussed in todays release.

<<<"Onyx Pharmaceuticals is engaged in the discovery and development of novel targeted, highly selective cancer therapies.
Based on its proprietary virus technologies, the company is developing CI-1042 as its lead product. CI-1042 is a therapeutic>>>"

Never heard of Onyx before today. The drug is being developed with Pfizer and is in P III.
tumor-selective, modified adenovirus (similar to the common cold virus) that has been genetically engineered to replicate in
and lyse (burst) cancer cells that have abnormal p53 pathway function while sparing normal cells that have functioning p53.
Derangements in the p53 protein pathway are the most common genetic abnormalities in human cancer. CI-1042 is currently
in a Phase III clinical trial for head and neck cancer and in Phase I and II clinical trials for a number of additional cancer
indications.
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