Bioorg Med Chem Lett 2001 Jan 8;11(1):51-4 Related Articles, Books
Antimitotic and cell growth inhibitory properties of combretastatin A-4-like ethers.
Lawrence NJ, Rennison D, Woo M, McGown AT, Hadfield JA
Department of Chemistry, UMIST, Manchester, UK. lawrencenj1@cardiff.ac.uk
[Medline record in process]
A series of diarylamines, diaryl and arylbenzyl ethers based on combretastatin A-4 was prepared and evaluated for anticancer activity. 2-Methoxy-5-(3',4',5'-trimethoxyphenoxymethyl)phenol was the most active (IC50, K562 20 nM) and caused significant G2/M cell cycle arrest.
PMID: 11140732 |
