I had missed this patent. This could be pretty cool. I always thought that hyperacute rejection was a weakness of BTRN's, and that Imutran/Sandoz complementation was an absolute necessity.
Don't know the significance of this one yet, caught off guard. But..... looks good.........
US6153428:.alpha.(1,3) galactosyltransferase negative porcine cells
Inventor(s):
Gustafsson; Kenth T. , Amersham, United Kingdom
Sachs; David H. , Newton, MA
Applicant(s):
BioTransplant, Inc., Charlestown, MA
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Issued/Filed Dates:
Nov. 28, 2000 / March 26, 1996
Abstract:
:
Transgenic swine in which the normal expression of .alpha.(1,3)
galactosyltransferase is prevented in at least one organ of tissue
type. The absence or inactivation of this enzyme prevents the
production of carbohydrate moieties having the distinctive terminal
Gal.alpha.1-3Gal?-4GlcNAc epitope that is a significant factor in
xenogeneic, particularly human, transplant rejection of swine grafts. |
