Vion (formerly Oncorx) interesting play on Gene Therapy Message Board

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Biotech / Medical : Vion (formerly Oncorx) interesting play on Gene Therapy

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To: Jim Oravetz who wrote (234)	3/26/2001 9:48:00 PM
From: Jim Oravetz	Read Replies (2) of 370

Replay of CC available till 3/30. About 40 min or so long. Very positive outlook, IMHO. Not a negative on Vion that AZ did not want to continue their involvement. Kessman indicated that going forward with the rest of PI trials would not present significant $$ drain. Late in the CC he was asked about funding - good till mid-2002. He said that the science should prove that even in a difficult capital market, money will follow. He is looking for funding sources on an on going basis. Levels of enzyme in cancer models were higher than if they put the enzyme directly into the cancer cells. AZ data was the same data sets that were prev. presented at the Lehman conf. PI trials must be completed to see that targets were really meet. They say high concentrations in cancer cells but none in non-cancer cells. However, even with the high concentrations, AZ did not like the degree of tumor shrinkage that they were expecting. There was a comment on a new "tethered" form of delivering the prodrug. Idealy, they would like to have as many as 14 trials (PI) starting this year! Other drugs in development, SHP and Triapine are also going well and there are higher expectations at Vion now than there were a year ago for these. Jim

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