Indications -- Lupus/Nephritis Message Board

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Biotech / Medical : Indications -- Lupus/Nephritis

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To: keokalani'nui who wrote (5)	4/5/2001 4:31:03 PM
From: keokalani'nui	Read Replies (1) of 95

List of drug candidates for SLE known to me. Disclaimer: I am not in the industry, and I do not represent this as complete or accurate. Genelabs Aslera (prasterone). NDA filed. Priority review. Arthritis advisory committee scheduled April 19, 2001. IDEC 131 Anti-CD40L Mab. In PII it did not demonstrate benefit, possibly sub-optimal dosing. IDEC going ahead in psoriasis and ITC. No word on going forward in lupus. ALXN 5G1.1, anti C5 Mab. Phase II started 8/99. Results expected late ’01. LJPH LJP 394, an oligonucleotide epitope that binds to serum alphaDNA and the B-cell surface to induce anergy. Phase III started 9/00. Tanox anti-CD40L Mab, small P1/2 in Chrohn’s. Lupus not yet a formal program. HGSI BlySys, preclinical BMS CTLA4-Ig. Not yet a formal lupus program DNDN Dantes (DN1921), an improved HLA-DR Mab. Preclinical. 3-D Pharmaceutical/Biocryst C1s-1. Preclinical. Cistron/Celltech Anti-IL-1beta Mab. Not sure what is happening here. IMNX IL-1 receptor. IND expected ‘01 Corixa (via Coulter) 64G12 Mab to subunit of Type I IFN. Preclinical Seattle Genetics SGN-30 Mab-drug conjugate. Preclinical. NBIX Altered peptide ligand in MS in PII. Lupus APL not on radar. Praecis PPI3088 small molecule inhibitor of NF-Kb. Research I hope to give a summary of the more advanced programs. --Wilder

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