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Biotech / Medical : Indications -- Lupus/Nephritis
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To: keokalani'nui who wrote (23)4/25/2001 2:13:07 PM
From: keokalani'nui  Read Replies (1) of 95
 
LJPC. anti-dsDNA.

I just read the Furie m/s on the PII 58 pt trial, which by the way merely correlates the drug to reduction in dsDNA and addresses safety (some concerns).

There are a number of interesting things in there, all requiring some faith in the approach.

1. [Generally] 'some patients with chronic elevations of dsDNA antibodies remain free of complications, suggesting that specific subsets of dsDNA antibodies are pathogenic.'

2. 'Although many patients with SLE do not produce dsDNA antibodies, most patients with proliferative lupus nephritis produce dsDNA antibodies....'

3. The mechanism by which LJP 394 results in a reduction in dsDNA antibody concentrations appears to be 2-fold. [immunoadsorption] and '...the drug may have induced B cell tolerance.' But 'the mode of action by which LJP 394 may induce tolerance is not known, but several...mechanisms...could be operable' [And there is speculation about how.]

It is this--no knowledge of if or how it could produce B cell anergy or prevent co-stimulatory signaling--that is of concern. Am I wrong, or aren't there many many efforts out there that are conducting such experiments privately or in academia? And, well admitting to but not knowing the answer about the 'subsets' of dsDNA....

There are 2 other LJPC m/s published last month containing data from other clinical trials. They were not in the stacks, or at least not available to me.

Hey, maybe it works great and who cares how. There does seem to be unanimous agreement that there is no safe effective treatment for SLE, MN. So good chances on them.

Wilder
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