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Biotech / Medical : Gene therapy

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To: Mike McFarland who started this subject	5/17/2001 10:29:43 AM
From: nigel bates	of 319

newscientist.com "...Another team, led by Fathman, used tissue-specific T cells. They added the gene for a protein which inhibits a molecule called IL-12. This molecule normally helps to activate the immune reaction that causes arthritis. When the researchers injected the modified T cells into mice with the disease, they migrated straight to the joints and suppressed the response, again alleviating the symptoms. Arthritis researcher Marc Feldmann from Imperial College in London says the research is interesting. "It tells us that gene therapy is alive and that there are prospects for the future," he says. But he warns that it could be at least ten years before patients are routinely treated in this way, because immune cells would have to be taken from the blood and modified for each patient individually. "It would be enormously costly and very inconvenient," he says.." More at: Journal of Clinical Investigation (vol 107, p 11490, 12037)

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