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On Tuesday, March 20, 2001, the U.S. Patent Office issued Patent No. 6,204,023, "Modular Assembly of Antibody Genes, Antibodies Prepared Thereby and Use". The claims are directed to processes for preparing immunoglobulins that are secreted from bacteria and are capable of antigen binding. This is the sixth patent issued to XOMA in its antibody expression family of patents and the third patent in this family that broadly covers methods for the secretion of functional immunoglobulins from bacteria, including single-chain antibodies and antibody fragments.
Bacterial antibody expression is a key enabling technology for the discovery and selection, as well as the development and manufacture, of many recombinant antibody-based pharmaceuticals. Antibody discovery by phage display technology, for example, depends upon expressing antibody domains in bacteria as properly folded, functional, secreted proteins, as described in XOMA's patent claims. |
