Genstar GNT(formerly UroGen)-- an interesting speculation Message Board

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Biotech / Medical : Genstar GNT(formerly UroGen)-- an interesting speculation

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To: tuck who wrote (73)	6/10/2001 9:06:49 PM
From: Elliot Lepler	Read Replies (1) of 100

Tuck, This article documents the success of the Target Genetics project. GenStar's viral treatment is much superior in several ways: 1) The TKTX process is individualized for each patient. Cells must be removed and processed in a case by case manner. GNT's viral preparation will be mass produced. 2) The TKTX process is extremely cumbersome and expensive. Cells must be harvested surgically and then cloned, grown, purified and finally reimplanted. The GNT virus is a single injection. 3) So far the TKTX process has produced factor VIII for just a few months. Animal studies with the GNT virus have demonstrated factor production for at least a year. With all that said, there remains the question of the immune response to the virus. It is quite possible that repeated injections will not be tolerated. If a viral approach can not work over the long term, other treatments will need to be perfected. In the meanwhile, I expect to hear of the first GNT patient treated soon. The recent media attention paid to hemophilia research should work to our benefit when the news of the first patient is released.

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