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Biotech / Medical : Celgene-CELG

CELG 108.24

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To: Miljenko Zuanic who wrote (542)	6/21/2001 8:26:19 PM
From: Mike K	Read Replies (2) of 804

As a myeloma patient let me chime in with my own anecdotal experience with thalidomide. Thalidomide is being used off-label as first line therapy for multiple myeloma. It is also being used as a maintenance drug following stem-cell transplant. I currently take the drug for maintenance following tandem transplants. It's a harsh drug with lots of side-effects but works very well. I know several patients who use the drug as first-line therapy alone or in combination with steroids such as prednisone or decadron.One woman friend has used thalidomide as her only myeloma treatment for 18 months and she's doing great. The issue of DVT is a widely known potential risk with DOX.The chemotherapy regime with DOX and thalidomide is very rough and I don't know many patients who have tolerated it well. It's main use is in the most drastic refractory cases. When I spoke with my oncologist earlier today, he did not expect the NEJM report to alter the use of thalidomide for myeloma treatment in any significant way. Cheers, Mike

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