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(COMTEX) B: PHOTOREFLECTANCE DUAL GRATING MONOCHROMATOR SYSTEM Solici B: PHOTOREFLECTANCE DUAL GRATING MONOCHROMATOR SYSTEM Solicitation June 22, 2001 (FIND, Inc. via COMTEX) -- NOTICE TYPE: Solicitation NOTICE DATED: 062001 OFFICE ADDRESS: Department of Commerce, National Institute of Standards and Tec nology (NIST), Acquisition and Logistics Division, 100 Bureau Drive, Building 30 , Room B129, Mail Stop 3571, Gaithersburg, MD, 20899-3571 ZIP CODE: 20899-3571 SUBJECT: 66 - PHOTOREFLECTANCE DUAL GRATING MONOCHROMATOR SYSTEM SOLICITATION NO.: SOL 01-812-1147 RESPONSE DEADLINE: DUE 062701 CONTACT: POC Tamara Grinspon, Contract Specialist, Phone (301) 975-4390, Fax (3 1) 975-8884, Email tamara.grinspon@nist.gov - Pauline Mallgrave, Supervisory Con ract Specialist, Phone (301) 975-6330, Fax (301) 975-8884, Email pauline.mallgra e@nist.gov NOTICE TEXT: The National Institute of Standards and Technology (NIST) intends to negotiate, on a sole source basis, under authority of FAR 13.106-1(b)(1), with Semiconductor Characterization Instruments, Inc., of Brooklyn, NY, for the purchase of one (1) Photoreflectance Monochromator System, with an option to purchase one (1) Acquisition and Analysis Hardware/Software package within one year from award of purchase order.*****The Semiconductor Characterization Instruments, Inc. system is the only proven, commercially-available system on the market that can perform the optical measurements of semiconductors required by NIST's Materials Technology Group.***** The Photoreflectance Monochromator System shall include: Photon Technology International monochromator with 1200 lines/mm and 750 nm blaze gratings, Xenon arc and tungsten-halogen lamp sources with stabilized power supply, dual phase 7265 Perkin-Elmer lock-in amplifier up to 100kHz, internally modulated 635 or 670 nm Coherent laser diode pump source, EG&G UV enhanced Si photodiode detector with preamplifier, variable neutral density filter normalization mechanism, assorted mirrors, lenses [quartz], holders and other optical components, vacuum chuck wafer holder for up to 6" wafers), and Surface Photovoltage Spectroscopy Option for Photoreflectance Monochromator System including special wire grid collection electrode and Photon Technology International chopper (up to 4 kHz).*****The Acquisition and Analysis Hardware/Software package (if the Government elects to purchase this option) shall include: Complete Windows NT software package for data acquisition, analysis (lineshape fits including third-derivative Lorentzian, first-derivative Gaussian, two-dimensional electron gas, Franz-Keldysh oscillations, etc.), manipulation and display, IBM compatible Pentium based 800 MHz personal computer, 17" monitor, and laser printer.*****Installation and a one-year warranty on parts and labor shall be included for both the Photoreflectance Monochromator System and the Acquisition and Analysis Hardware/Software package.*****Delivery shall be FOB Destination, Gaithersburg, MD, and is required 56 days or less from receipt of purchase order (ARO).*****The North American Industry Classification System (NAICS) code for this acquisition is 334516, and the size standard is 500 Employees.*****No solicitation package will be issued. This notice of intent is not a request for competitive quotations. However, responses received by June 27, 2001 will be considered by the Government. A determination by the Government not to compete the proposed acquisition based upon responses to this notice is solely within the discretion of the Government. Information received will normally be considered solely for the purpose of determining whether to conduct a competitive procurement.=20 - Visit this URL for the latest information about this notice RECEIVED: (D-171 SN50P5P7) Issue No. PSA-2876 URL: eps.gov Copyright (c) 2001: FIND, Inc. -0- INDUSTRY KEYWORD: ITL SUBJECT CODE: GVC 66 -- Instruments and Laboratory Equipment *** end of story ***
Photon Technology International, Inc. (the "Company" or "PTI(R)") is a New Jersey based high technology corporation, incorporated in November 1983. PTI is engaged in the business of exploiting the many applications of the proprietary fluorescence technology that it has developed.
Fluorescence is a relatively new technique that offers the following user benefits:
o sensitivity - can detect 10,000,000 times smaller quantities than conventional techniques
o speed - can detect 1,000,000 times faster than conventional techniques
o universal - some substances fluoresce directly, others can be made to fluoresce, by means of fluorescence dyes that are specific to that substance
o safe and can be used in vitro - the only competing technique is radio active labeled substances, obviously much less desirable.
o cost competitive
Fluorescence is used to:
o measure minute amount of substances - can detect much smaller quantities than by any other means
o measure changes in substances over time - the time can be very short
o show where substances of interest are located - can be visually observed through a microscope o trace where substances are migrating
Examples of fluorescence applications are:
o environmental studies - how much pollutant; where is it located; where does it originate
o pharmaceutical studies - drug affects
o process control - impurities, contaminants
o medical - detection of diseases in early stages, such as: cancer, Alzheimer's, heart, kidneys, nervous disorders - diagnostic - causes of diseases - research - reaction and monitoring of treatment
o agriculture o foods - detection of bacteria and contaminants, measurement of freshness
Fluorescence applications are growing, and can be found in virtually every field, where the detection and monitoring of minute substances is of significance.
PTI has developed a full line of proprietary and/or patented fluorescence based instrumentation to serve as a platform for the exploitation of this useful technique.
PTI moved its head offices from Monmouth Junction, New Jersey to Lawrenceville, New Jersey in July 2,000. PTI sells its products in North America through a direct sales force, located in four different sales offices in the U.S. and Canada.
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In June of 1987, the Company incorporated a wholly owned subsidiary, Photon Technology International (Canada) Inc., located in London, Ontario, Canada ("PTI Canada"). PTI Canada's operations include manufacturing, research and development, engineering and product support. PTI consolidated all in-house manufacturing in Canada when it recently moved its head offices in New Jersey and expanded the Canadian plant. The lower Canadian currency and labor costs coupled with the availability of skilled labor, makes PTI's production more cost effective.
Formerly European sales, service, distributors and product distribution were managed from offices located in London England, through an unincorporated branch office of the Company (PTI UK). In September of 1994, PTI established a 51% owned subsidiary, PhotoMed GmbH in Wedel, Germany, to handle sales and service in Germany, Austria, Benelux and Scandinavia, through a direct sales force. In July of 1995, PTI acquired 100% of the subsidiary. On December 1st 1999, PhotoMed was sold to Charles Marianik the President of PTI. The PhotoMed entity will continue to distribute PTI's product in the same geographical area as its primary business. In addition, PhotoMed has taken over service support for all of Europe. The intent of the sale of PhotoMed is to gain access to European financing in order to expand the sales and marketing of PTI's products in Europe and to free up financial resources of PTI for marketing and sales in the rest of the world.
In April of 1987, the Company entered into a research agreement with M.L. Technology Ventures L.P. ("MLTV") to develop four different products. PTI has successfully completed the products under the agreement. MLTV's interest in the products have been taken over by PTI in exchange for 333,333 common shares of the Company in December 1995.
The Company is focused on the fluorescence market place. PTI believes fluorescence is a multi-billion dollar market, enjoying substantial growth. PTI has the ability to identify commercial and scientific applications through its technical and design capability and to provide products which "add value" to the end users and which are responsive to these needs. This ability is key to the Company's success. The Company's know-how that is employed in its design and assembly techniques results in competitive products which have high precision, quality and lower cost.
Industry
The Company operates in what can be broadly defined as the photonics industry. The photonics industry utilizes light for application in medical research and testing, pharmaceutical drug development, industrial process and quality control, and environmental, research monitoring and control. It is a relatively new industry, having only emerged in the 1970s.
Light-based instrumentation for industry, medicine, and research is a multi-billion dollar business. As a result, applications for photonics instrumentation and techniques for medicine are still emerging. The Company's industry niche utilizes fluorescence technology to measure samples in small amounts or quantities, track movement/location, monitor chemical or physical changes and identify or isolate the sample from the surrounding environment. In medical research applications and drug development, this can be accomplished without harm or destruction to the sample (i.e. cells). In all applications the speed, sensitivity and light reaction are important for process, quality control and monitoring.
Technology
The application of light in the fields of industry, medicine, and research falls into many broad categories. Among these is a phenomenon called "fluorescence." It is this phenomenon that PTI's instruments are designed to create and measure.
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When light strikes a substance, the light is absorbed and then re-emitted. If the wavelength of light that is re-emitted is different from that which is absorbed, then the substance is said to have fluoresced. By stimulating fluorescence and monitoring its location and intensity, scientists can identify the concentration and changes of substances. While not all substances fluoresce, it is possible to create a dye (also called a probe) that will cause non-fluorescent substances to fluoresce.
While the phenomenon of fluorescence is certainly not new, applications for the technique are new and emerging. The recent development of fluorescent dyes has made fluorescence the most exciting tool in the industry today. Practical applications for new dyes and assays are being discovered almost on a daily basis. Fluorescence is now a multi-billion dollar industry.
Fluorescence is a powerful and rapidly expanding tool for cellular and sub-cellular testing because it is:
o more sensitive than other means of detection (about a factor of 1,000,000 times more) which means that very small, sub-cellular amounts of substances can be detected and measured with great accuracy.
o safer than other means of detection, because it is non-invasive (does not physically injure the cell) and non-radioactive (avoids health and disposal problems).
o faster than other means - it can monitor changes in trillionths of a second, or about 1,000,000 times faster than other techniques.
o a visual process - microscopic images can be gathered and displayed, for example, showing changes inside living cells.
o less expensive than other techniques, which means it can do more work for less money, while saving time, resources and even lives.
Products
PTI initially developed a line of proprietary and/or patented optical building blocks ("OBB's") which form the basis of all light based instrumentation. The Company sells these building blocks as stand alone units. In addition PTI uses these unique building blocks to develop its open architecture fluorescence systems. The open architecture offers the benefits of:
o more versatile equipment - more options o customers can buy upgrades and options as they need them or can afford them o less time for development of new systems - PTI can more rapidly meet new market demands o less chance of product obsolescence o lower costs
PTI has many new products that it will be introducing over the next three years, some of which are its own manufacture, some as a result of corporate parting with other companies. PTI in light of the new product expansion, will continue to upgrade and reorganize its product lines in order to be more effective in marketing and sales. The two main divisions in the product groups are components, Product Group I and systems, Product Groups II, III and IV.
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Product Group I - Optical Building Blocks
PTI's components make up this line. They are composed of: - light sources, both conventional and nitrogen and dye lasers - fiber optic illuminators - light and sampling handling modules, - various detectors using: photomultipliers, photodiodes and intensified CCD cameras, - microscope accessories that can be used with virtually any manufacturers microscopes (PTI does not manufacture microscopes.)
PTI has introduced a new line of power supplies and starters for its light sources that reduce RF interference, which has traditionally been a problem with such products since they are used in places where computers and other sensitive instrumentation are subject to interference from the RF. In addition the power supplies and starters are lower in cost of manufacture.
PTI is currently test marketing a new light source line that will offer even more efficient power output than its current light sources. Full product introduction is anticipated in January of 2001. PTI has applied for patent.
As a result of a joint partnership with M.U.T., a German engineering Company, PTI is introducing a new intelligent, portable spectrophotometer. This device has the capability to detect many different types of substances or to analyze light, such as color detection. In addition to the two current models PTI will introduce a full line of accessories. Currently the product is being marketed through the component group, but it is expected that over the next few years the product will become an independent product line.
This product line has a very broad market, since these modules can be used wherever light is used. In addition, the modules are being sold as single units, as well as in several PTI systems. There are significant O.E.M. applications that PTI is currently actively pursuing. This product line is PTI's oldest. The products have been totally redesigned and kept up to the latest technology and specifications.
Product Group II - Fluorescence Microscopy and Imaging
This is a new product line that was reorganized to combine all microscope based fluorescence systems under one product line. Formerly the products were under two separate product groups, the Ratio-Fluorescence Systems (excluding imaging) - RatioMaster Line and the Fluorescence Imaging Systems ImageMaster Line.
The RatioMaster products were the first PTI systems, introduced in 1987. The RatioMaster systems can detect various ions, or fluorescent-labeled compounds, generally found in living organisms. The products have a wide range of applications in the medical, life science and pharmaceutical areas. They are currently used for research applications to diagnose diseases, monitor drug effects, or to understand various functions of living organisms. The systems can be used to study, in-vivo: tissues, cells, single cells or even events happening at sub-cellular levels.
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Because the ImageMaster systems are used with PTI's RatioMaster systems and with microscopes and therefore serve very similar markets PTI has decided to incorporate them into the same product line. Imaging gives the added dimension of spatial resolution. Not only can one detect and measure substances, but one can also tell where they are - or if they are on the move - where they are moving.
The patented RAM technology, developed with the MLTV funding, continues PTI's technological leadership in this area. The RAM technology is used with both RatioMaster and ImageMaster systems.
Added to this product line in the next fiscal year is the new fluorescence microscopy systems (January 2001). These systems are used for routine fluorescence applications in microscopy.
Product Group III - Spectrofluorometers - QuantaMaster
PTI has recently entered the largest single market in the fluorescence area. Steady state fluorimeters are used in most basic fluorescence applications wherever one has to detect small amount of substances, such as: environmental, pharmaceutical, chemical, medical and process control.
PTI's modular architecture and price is unique in this market. The Company is continuing to add options and accessories to complete the product line. Sales have continued to increase at a steady state for this product line, but PTI is looking at additional financing to fully exploit this product line.
Product Group IV - Fluorescence Life-Time Systems - TimeMaster
TimeMaster(TM) systems are used to determine fluorescence lifetimes, a technique used to distinguish between similar substances. The fluorescence lifetime represents the average time that a molecule spends in an excited state before emitting a photon and returning to the ground state. It is an important and unique feature of an excited state. Fluorescence lifetimes are very short. Most fluorescence lifetimes fall within the range of hundreds of picoseconds to hundreds of nanoseconds. The fluorescence lifetime can function as a molecular stopwatch to observe a variety of interesting molecular events. An antibody may rotate slightly within its molecular environment. A protein can change orientation. A critical binding reaction may occur. Because the time-scale of these events is similar to the fluorescence lifetime, the measurement of the fluorescence lifetime allows the researcher to peer into the molecule and observe these phenomena.
In late fiscal 1994, the Company introduced a revolutionary newly patented design, and the most economical systems for fluorescence lifetime measurements, the TimeMaster(TM) fluorescence Lifetime Spectrometers. These systems revolutionized the fluorescence lifetime techniques by designing easy-to-use systems which are consistent with the Company's modular and open architecture strategy for products. Research and development efforts by the Company during fiscal 1994 and 1995 provided a product line with a unique strobe technique, a choice of two different lifetime techniques and three different base system configurations as follows:
StrobeMaster(TM) provides a unique and patented strobe technique for measuring fluorescence lifetimes which is economical to use. The strobe technique is intensity dependent and provides accurate measurements at very high speeds. These characteristics of the strobe technique are very important in the life sciences area, where samples are not stable over long periods of time. The StrobeMaster(TM) uses a NanoFlash(TM) illuminator source.
LaserStrobe(TM) is based on the strobe technique for measuring fluorescence lifetimes and is as unique as the StrobeMaster(TM). With a nitrogen/dye laser
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illumination source, the strobe technique provides for measurements of lifetimes with a precision of below one nanosecond.
The unique strobe technique, through the introduction and sales of the StrobeMaster(TM) and LaserStrobe(TM), has started to be recognized and accepted for measuring fluorescence lifetimes as evidenced by the increase in sales of these systems during the early part of the current 2001 fiscal year.
New Product Application Developments
In addition to the development of new or improved products, PTI has started to focus on new and emerging applications that have great future potential. Although these applications may be long term, the lessons learned can be incorporated into existing products keeping PTI's instrumentation state of the art. Given PTI's limited financial resources, we have been judicious in pursuing only a select few hot new opportunities.
New this year is the application of PTI's expertise in fluorescence microscopy to forensics. PTI has developed and sold a specially developed forensic microscopy system for a major U.S. crime lab for the identification of various traces of substances that are found at a crime scene. PTI is currently examining if this market niche is economically viable, since the Company has the expertise to develop routine equipment for use in these types of applications.
PTI's fluorescence instrumentation this summer took a trip with the world famed submersible Elvin, of Titanic fame. The submarine explored black smokers more than a mile in depth on the ocean floor for signs of living organisms, where PTI's instrumentation was used in studying these samples.
PTI will continue to explore the frontiers of science in fluorescence applications. Currently PTI has been invited to explore fluorescence applications in outer space. |