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Biotech / Medical : DYAX: Dyax Corp.

DYAX 38.41

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Jan 25 4:00 PM EST

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To: keokalani'nui who wrote (3)	7/5/2001 10:53:16 PM
From: aknahow	of 197

Xoma said this about its' phage operations. Full release at xoma.com Bacterial antibody expression is also a key technology for high-throughput screening of antibody domains in multiple systems. Expression of antibodies by phage display technology, for example, depends upon the expression and secretion of antibody domains from bacteria as properly folded, functional proteins. Therefore, access to XOMA’s patent estate is necessary for the practice of antibody phage display and other antibody screening applications. XOMA has offered licenses to a number of companies that use such technologies extensively for themselves and others in the discovery and development of commercially useful antibodies. About Antibody Phage Display Antibody phage display has become a particularly useful method for identifying and selecting novel molecules for drug development; a number of companies focus their efforts in the phage display area. This technique can rapidly identify individual antibodies with unique binding properties to selected targets from large populations of antibody molecules. Companies use phage display to screen antibody libraries for the discovery and development of therapeutic and diagnostic drug candidates, an area of renewed focus due to the recent clinical successes of several therapeutic antibodies. Bacteriophage ("phage") are viruses that infect bacteria and reproduce by borrowing the cellular replication apparatus of the bacterial cells. The phage particles most useful for antibody phage display contain a single-stranded DNA molecule enclosed in a protein coat. The antibody genes are genetically engineered into the phage DNA (genotype) and introduced into bacterial host cells, which secrete phage particles on their cell surfaces. The antibody protein that binds to a particular target (phenotype) is expressed as a fusion protein on the surface of the phage particle. This direct linkage of genotype with phenotype in a single particle makes phage display technology a widely recognized and especially efficient discovery tool. The use of phage display in screening for novel high-affinity ligands and their receptors has been particularly useful in functional genomics and proteomics.

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