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Biotech / Medical : Kosan BioSciences -- KOSN
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To: keokalani'nui who wrote (19)7/18/2001 8:31:15 PM
From: keokalani'nui  Read Replies (1) of 933
 
Didn't see this doubletwist article posted here before.

doubletwist.com

...Kosan scientists have been able to clone the DNA responsible for the six enzymes that construct epothilone and introduce it into the microbe Streptomyces coelicolor. The ability of this engineered bug to recombinantly produce epothilone was reported in Science in January 2000, and the company is currently trying to scale up production of the compound.

For investors, that success, if matched by success in ramping up production and proving the safety and efficacy of epothilone D, will spell a home run for Kosan. But what may be more interesting for the long-term prospects of the company is the fact that they've shown an ability to successfully manipulate genetic information to engineer the production of polyketides. It's no small task, requiring the manipulation of various enzymes in a metabolic pathway such that they make predictable and desirable changes to an end product. But as Santi is quick to point out, it is a "modular" system that Kosan now knows well. Polyketides are chain or ring structures made up of ketone groups, and are present in the natural world in great abundance and variety. They usually are produced by fungi or bacteria like actinomycetes. (There's more.)

Wilder
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