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Biotech / Medical : Oxford GlycoSciences Plc

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To: Jongmans who started this subject	8/7/2001 9:44:26 AM
From: nigel bates	of 469

Genzyme was the first to successfully employ protein remodeling technology in the 1980s when it used a different process to produce Ceredase® (alglucerase) and Cerezyme® (imiglucerase for injection) for Type 1 Gaucher disease. The products are, respectively, natural and recombinant forms of glucocerebrosidase for which the glycosylation of the enzyme has been modified so that it is mannose terminated and therefore more easily recognized and taken up by the macrophage cells that accumulate lipids. Applying Novazyme's technology to create highly phosphorylated glucocerebrosidase, could represent a next-generation version of Cerezyme. Message 16177750

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