Indications -- Psoriasis/Chronic Inflammation Message Board

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Biotech / Medical : Indications -- Psoriasis/Chronic Inflammation

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To: Mark Bong who wrote (97)	8/8/2001 3:45:14 PM
From: scaram(o)uche	Read Replies (1) of 631

>> b) higher incidence of HSV reactivation in treated groups << A couple of months ago, I mentioned that I would not take, on an ongoing (chronic) basis, an anti-CD11a. I cited a fear of, as an example, oral mucositis. Or perhaps I mentioned an increased frequency and/or severity of shingles. Maybe I mentioned both. Whatever. George has differentiated between rebound and flare. If flare is severe, even in a small percentage of patients, then I believe that Xanelim is in trouble. Despite my vested interest in 507, I'm pulling for Xanelim. Nonetheless, the talk of taking it for the remainder of one's life is, IMO, dangerous. >> d) suspicious malignancy rate--Genentech hemmed and hawed for long periods at the end of the conference call: "we won't review the case-by-case records" << For prolonged (chronic) admin, I'd predict an increased frequency of B lymphoma, cervical carcinoma, etc.

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