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Biotech / Medical : VD's Model Portfolio & Discussion Thread

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To: Andrew H who wrote (1309)	6/20/1997 12:30:00 AM
From: Vector1	of 9719

PB, there has been alot of discussion on this and other threads regarding HAMA reaction from the Murine derived Bexxar MA. Tell me if I am crazy but I believe a Murine based MA is a better compound to conjugate a radioactive pharma than a human derived MA. The reason is that the Murine MA is flushed out of the system much more quickly allowing for higher doses of radiation. Since the reaction is not that severe, Bexxar is a one shot knockout punch and it only occurs in about 20% of patients I don't see it as a major issue. Interestingly it is my understanding that IDPH's radioconjugate Y2B8 uses a murine MA. V1

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