re. Medinox.......
Neurology 2001 Sep 11;57(5):892-894
Cooling garment treatment in MS: Clinical improvement and decrease in
leukocyte NO production.
Beenakker EA, Oparina TI, Hartgring A, Teelken A, Arutjunyan AV, De Keyser J.
Department of Neurology (Drs. Beenakker, Teelken, and De Keyser, and A. Hartgring),
Academisch Ziekenhuis Groningen, The Netherlands.
Ten heat-sensitive patients with MS were randomly allocated in a cross-over study to wear a
cooling garment for 60 minutes at 7 degrees C (active cooling) and 26 degrees C (sham cooling).
In contrast to sham cooling, active cooling improved fatigue and postural stability with eyes
closed and muscle strength. There was no decrease in tympanic temperature, but active cooling
was associated with a 41% decrease in mean leukocyte nitric oxide (NO) production (p =
0.004). This effect on NO could be relevant because it blocks conduction in demyelinated axons. |
