vaccines Message Board - Msg: 16487634

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Biotech / Medical : vaccines

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To: nigel bates who wrote (7)	10/11/2001 10:52:18 AM
From: keokalani'nui	Read Replies (1) of 26

MAXY. New Adjuvant and Cancer Vaccines. snip Therapeutic Cancer Vaccine -- Last year Maxygen announced the advancement of a therapeutic cancer vaccine it is developing internally. Today, Maxygen announced that this cancer immunotherapeutic is a DNA-based vaccine for colorectal cancer that is comprised of a novel shuffled immunostimulatory adjuvant termed "CD28BP" and a colon cancer-associated antigen. While the initial indication for this product is colorectal cancer, Maxygen believes its product may also be useful for treating ovarian, lung and prostate cancers. -- B7.1 (CD80) is a co-stimulatory molecule that activates T cells and is crucial in the regulation of a number of immune responses. Maxygen's proprietary CD28BP induces a T cell proliferation response that is even greater than that induced by B7.1. The novel characteristics of CD28BP may facilitate the development of cancer vaccines by facilitating a stronger immune response to the cancer-associated antigen than would be achieved by using the antigen alone or in combination with B7.1. snip From 10/11/01 PR. Wilder

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