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Biotech / Medical : New Brunswick Scientific Co., Inc. (NBSC)

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To: scaram(o)uche who wrote (283)	10/17/2001 1:06:16 PM
From: scaram(o)uche	Read Replies (1) of 724

Pillutla, six manuscripts, all first author. Here's the last before DGI............ Genomics 1999 Mar 1;56(2):217-20 Genomic structure and chromosomal localization of TCEAL1, a human gene encoding the nuclear phosphoprotein p21/SIIR. Pillutla RC, Shimamoto A, Furuichi Y, Shatkin AJ. Center for Advanced Biotechnology and Medicine, 679 Hoes Lane, Piscataway, New Jersey 08854-5638, USA. Human p21/SIIR is a novel Ser/Arg/Pro-rich nuclear phosphoprotein that is 48% similar to transcription factor SII and modulates transcription in a promoter context-dependent fashion. We have obtained the complete sequence of TCEAL1, the gene that codes for p21/SIIR. This gene consists of three exons and two introns with the entire coding sequence in exon III. Tissue-specific expression patterns of TCEAL1 by Northern blot analysis showed the presence of an approximately 1.2-kb transcript in all normal human tissues examined, and heart and skeletal muscle contained an additional transcript of approximately 7 kb. Expression was lowest in hematopoietic cells of both normal and tumor origin. TCEAL1 was mapped to human chromosome Xq22.1 by fluorescence in situ hybridization.

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