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Biotech / Medical : IDPH--Positive preliminary results for pivotal trial of ID

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To: I. Luttichuys who wrote (1059)6/25/1997 4:51:00 PM
From: Pseudo Biologist   of 1762
 
Bennet, are you saying that this is a general problem for *any* anti-CD4 antibody? If so, even the plan II, back up, Ab would be doomed as well; ditto for the OKT4A (J & J) and the Glaxo-Wellcome humanized anti-CD4's.

Speaking in (very) general terms, one can argue that these anti-"many" (CD4, CD3, CD2 - meaning markers present in a large portion of the T-cell population) immunoregulating strategies are sort of shotgun first-generation approaches. As one understands the molecular basis of RA and other auto-immune conditions a bit better, it may be possible to come up with more selective targets that do not shut down an entire arm of the immune system. Still, as you suggested in a previous post, the information given in the press release and in statements to BioWorld leaves room for the notion that the CE9.1 situation is not beyond hope.

PB
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