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Biotech / Medical : Cambridge Antibody Technology Group

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To: keokalani'nui who wrote (211)	11/16/2001 12:56:12 PM
From: tuck	Read Replies (1) of 625

About the only difference I can see versus the three month results are more evidence of statistical significance: Message 16243388 >>Intraocular pressure (IOP) was successfully lowered by surgery in both patient groups. Six months after operation the achieved IOP was lower in patients receiving CAT-152 (mean value 14.5 mmHg) compared to those receiving placebo (mean value 16.7 mmHg). The proportion of patients achieving IOP below 22 mmHg was: CAT-152 100%, placebo 80% (p = 0.013). At lower IOP thresholds a similar trend was seen (less than 18 mmHg: CAT-152 83%, placebo 65%; less than 15 mmHg: CAT-152 50%, placebo 30%). In the early post-operative period intervention with 5FU injection was used in 10 of 36 (28%) CAT-152 treated patients compared to 2 of 20 (10%) on placebo. By six months after surgery resumption of long term topical IOP lowering medication was needed in 3 of 36 (8%) CAT-152 treated patients compared to 3 of 20 (15%) on placebo. One of these three placebo patients subsequently underwent repeat trabeculectomy to control IOP.<< snip; emphasis mine They only give p number for patients below the highest IOP, and that number is only good, not great, right? One likes to see two zeros right of the decimal? Don't think you're missing anything, Wilder. Risk/reward on this program looks so-so to me. I bailed for a small, nerve-wracking gain on its recovery to $27.5 a couple of weeks ago. Thinking that things have gone too well in the war, that Mr. Market is due for a breather. That CAT could see low 20s again, at which point I like it better. Cheers, Tuck

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