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Biotech / Medical : AVIGEN(avgn)

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To: SnowShredder who wrote (199)	11/16/2001 6:29:16 PM
From: JMarcus	Read Replies (1) of 228

Yes, Monahan specifically stated that the DNA fragments are no longer showing up in the 64-year old's semen. He didn't say how long it took before the PCR tests started coming up non-detect. The vector was administered in August. 10/8/2001 is the date of the press release announcing the semen results. Sounds like about 2 months passed between administration and detection and that by 3 months after administration non-tection was achieved. The PR said: <<Under the protocol, this step [a clinical hold] is required if the vector is identified in the semen of a patient, which was determined to be the case using sensitive assays.>> Monahan specifically said that the use of the word "vector" was a mistake. He stressed that it was just DNA fragments and not complete vectors that were detected in the semen. Monahan said that 99.9% of the vector stayed in the liver. Just trace amounts of vector or DNA fragments (just DNA fragments in the case of the semen -- not sure whether it was just fragments or whole vectors in the serum and saliva) were found in serum, saliva and semen. I see that on Nov. 7th AG Edwards initiated coverage with a Strong Buy. The stock seems to be at near firesale prices, but I worry about that RAC meeting. Marc

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