just parking, not certain of relevance.......
Am J Kidney Dis 2001 Nov;38(5):956-64
Increased prevalence of combined MTR and MTHFR genotypes among
individuals with severely elevated total homocysteine plasma levels.
Feix A, Fritsche-Polanz R, Kletzmayr J, Vychytil A, Horl WH, Sunder-Plassmann G,
Fodinger M.
Department of Medicine III, Division of Nephrology and Dialysis, Division of Endocrinology and
Metabolism, University of Vienna, Austria. alexandrafeix@hotmail.com
The prevalence of the methionine synthase (MTR) 2756A-->G polymorphism among individuals
with severely elevated total homocysteine (tHcy) plasma levels is unknown. Therefore, 1,716
subjects, including 415 hemodialysis patients, 179 peritoneal dialysis patients, 733 kidney graft
recipients, and 389 healthy subjects, were investigated. The distribution of MTR 2756A-->G, as
well as 5,10-methylenetetrahydrofolate reductase (MTHFR) 677C-->T/1298A-->C, genotypes
among study participants with extremely high tHcy plasma levels (>90th percentile) was
compared with the genotype distribution of subjects with very low tHcy plasma levels (`10th
percentile). The prevalence of MTR 2756AG and GG genotypes alone did not differ between
individuals with extremely high or extremely low tHcy levels (P = 0.7402; odds ratio [OR],
1.076; 95% confidence interval [CI], 0.697 to 1.662). Conversely, combined MTR and
MTHFR genotypes (MTR 2756AG and 2756GG and MTHFR 677TT/1298AA and
677CT/1298AC) were found more often in the highest (n = 34) compared with the lowest
plasma tHcy decile (n = 19; P = 0.0252; OR, 1.983; 95% CI, 1.079 to 3.643). The number of
patients with the wild-type MTR and MTHFR genotype was three times greater in the lowest
compared with the highest decile (17 versus 6 patients, respectively; P = 0.0155; OR, 0.330;
95% CI, 0.126 to 0.861). In summary, our study shows that the 2756A-->G transition of MTR
in combination with MTHFR 677TT/1298AA and 677CT/1298AC can be associated with
extremely high tHcy plasma levels. |
