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TABLE 1 Class Pathway Function Name OMIM GID Locus Absorption Gastrointestinal Glycosidases
sucrase-isomaltase/S1 222900 NM_001041 3q25-q26 and Drug Metabolism
maltase-glucoamylase/alpha-glucosidase/MGAM 154360 NM_004668 Chr.7 Distribution lactase-phlorizin
hydrolase/LPH/lactase/LCT 603202 NM_002299 2q21 salivary amylase A/AMY1A 104700 NM_004038 1p21 salivary
amylase B/AMY1B 104701 ****** 1p21 salivary amylase C/AMY1C 104702 ****** 1p22 pancreatic amylase
A/AMY2A 104650 X07057 1p21 pancreatic amylase B/AMY2B 104660 ****** 1p21 Proteases and dipeptidylpeptidase
IV/CD26/ADA complexing 102720 NM_001935 2q23 Peptidases protein 2/DPP4 pepsinogen A/PGA/PG 169700
AH001519 11q13 pepsinogen, group 3/PGA3 169710 ****** 11q13 169740 J04443 6p21.3- pepsinogen C/PGC q21.1
147910 AH002853 19q13.2- q13.4 chymotrypsin-like protease 118888 X71875 16q22.1 trypsinogen 1/TRY1/protease,
serine 1/PRSS1 276000 NM_002769 7q35 trypsinogen 1/TRY2/protease, serine 2/PRSS2 601564 NM_002770 7q35
trypsinogen 1/TRY3/protease, serine 3/PRSS3 ****** NM_002771 ****** enterokinase 1/TRY3/protease, serine7/PRSS7
226200 NM_002772 21q21 chymotrypsinogen 1/CTRB1 118890 NM_001906 16q23.2- q23.3 carboxypeptidase
A1/CPA1 114850 NM_001868 7q32-qter carboxypeptidase A2/CPA2 600688 NM_001869 ****** carboxypeptidase
Z/CPZ 603105 NM_003652 elastase 1/ELA1 130120 D00158 12q13 renal microsomal dipeptidase/DPEP1 (b-lactam ring
179780 NM_004413 16q24.3 hydrolysis) tripeptidyl peptidase II/TPP2 190470 NM_003291 13q32- q33 protease inhibitor
1/alpha-1-antitrypsin/AAT/PI 107400 NM_000295 14q32.1 protease inhibitor/alpha-1-antichymotrypsin/AACT 107280
NM_001085 14q32.1 protease inhibitor 1 (alpha-1-antitrypsin)-li- ke/PIL 107410 NM_006220 14q32.1 Lipases Carboxyl
ester lipase (bile salt-stimulated 114840 M85201 9q34.3 lipase)/CEL Carboxyl ester lipase-like (bile salt-stimulated lipase-
114841 NM_001808 9q34.3 like)/CELL Pancreatic colipase/CLPS 120105 M95529 6pter- p21.1 Pancreatic triglyceride
lipase/PNLTP 246600 AH003527 10q26.1 Lipoprotein lipase/LPL 238600 NM_000237 8p22 Hepatic triglyceride
lipase/LIPC 151670 AH005429 Oxidases salivary peroxidase/SAPX 170990 U39573 ****** alcohol dehydrogenases
6/ADH6 103735 NM_0006721 15q26 Esterases paraoxonase 2/PON2 602447 L48513 7q21.3 Phosphatases intestinal
alkaline phosphatase/ALPI 171740 NM_00163 12q36.3- q37.1 tissue non-specific alkaline phosphatase/liver 171760
1p36.1- alkaline phosphatase/ALPL NM_000478 p34 Drug Binding Blood Transport serum albumin/ALB 103600
NM_000477 4q11-q13 alpha fetoprotein/AFP 104150 NM_001134 4q11-g13 alpha albumin/afamin/AFM/ALB2 104145
NM_001133 4q11-q13 vitamin D-binding protein/group-specific 139200 AH004448 4q12 component/GC orosomucoid
1/alpha 1 acid glycoprotein/ORM1 138600 M13692 9q34.1- q34.3 orosomucoid 2/alpha 1 acid glycoprotein, type 138610
NM_000608 9q34.1- 2/ORM2 q34.3 transthyretin (prealbumin, amyloidosis type I)/TTR 176300 NM_000371 18q11.2-
q12.1 thyroxin-binding globulin/TBG 314200 NM_000354 Xq22.2 corticosteroid binding globulin precursor/CBG 122500
NM_001756 14q32.1 sex hormone-binding globulin/SHBG 182205 X16349 17p13- p12 mannose-binding lectin,
soluble/MBL2 154545 NM_000242 10q11.2- q21 Bile Acid Hepatic fatty acid binding protein/FABP1 134650 ******
2p11 Binders Intestinal fatty acid binding protein/FABP2 134640 NM_000134 4q28-q31 Muscle fatty acid binding
protein/mammary-derived 134651 NM_004102 1p33-p31 growth inhibitor/MDGI/FABP3 Adipocyte fatty acid binding
protein/FABP4 600434 NM_001442 8q21 Ileal fatty acid binding protein/FABP6 600422 U19869 5q23-q35 Brain fatty
acid binding protein/FABP7 602965 D88648 6q22-q23 Adipocyte long chain fatty acid transport 600691 ****** ******
protein/FATP Drug Uptake ABC Retina-specific ATP binding cassette 601691 NM_000350 1p21-p13 Transporters
transporter/ABCR ATP binding cassette 1/ABC1 600046 AJ012376 9q22-q31 ATP binding cassette 2/ABC2 600047
U18235 9q34 ATP binding cassette 3/ABC3 601615 NM_001089 16p13.3 ATP binding cassette 7/ABC7 300135
AB005289 Xq13.1- q13.3 ATP binding cassette 8/ABC8 603076 AF0381752 1q22.3 ATP-binding cassette 50/ABC50
603429 AF0273026 p21.33 Placenta-specific ATP-binding cassette 603756 NM_004827 4q22 transporter/ABCP cystic
fibrosis transmembrane conductance 602421 NM_000492 7q31.2 regulator/CFTR
adrenoleukodystrophy/adrenomyeloneuropathy/ALD 300100 NM_000033 Xq28 adrenoleukodystrophy related
protein/ALDR 601081 U28150 12q11- q12 sulfonylurca receptor (hyperinsulinemia)/SUR 600509 NM_000352 11p15.1
peroxisomal membrane protein 1/PXMP1 170995 NM_002858 1p22-p21 peroxisomal membrane protein 1-like/PXMP1L
603214 NM_005050 14q24.3 antigen peptide transporter 1/MHC 1/TAP1 170260 NM_000593 6p21.3 antigen peptide
transporter 2/MHC 2/TAP2 170261 NM_000544 6p21.3 multidrug resistance associated protein MRP1 158343 L05628
16p13.1 multidrug resistance associated protein 601107 NM_000392 10q24 MRP2/CMOAT ATP-binding cassette,
sub-family C (CFTR/MRP), ****** ****** member 3/CMOAT2 NM_003786 ATP-binding cassette, sub-family C
(CFTR/MRP), ****** NM_005845 ****** member 4/MOATB ATP-binding cassette, sub-family C (CFTR/MRP),
****** NM_005688 ****** member 5/SMRP ATP-binding cassette, sub-family C (CFTR/MRP), 601439 NM_005691
****** member 9/SUR2 multidrug resistance protein MDR1 171050 X96395 7q21.1 multidrug resistance protein
MDR3/P-glycoprotein 602347 X06181 7q21.1 3/PGY3 anthracyleline resistance-related protein/ARA 603234 NM_001171
16p13.1 bile salt export pump/BSEP 603201 NM_003742 2q24 familial intrahepatic cholestasis 1/FIC1 602397
NM_005603 18q21 Human sorcin/SRI 182520 L12387 7q21.1 Solute Solute carrier family 1, member 1/SLC1A1 133550
U08989 9p24 Antiporters (glutamate) Solute carrier family 1, member 2/SLC1A2 600300 U03505 11p13- (glutamate) p12
Solute carrier family 1, member 3/SLC1A3 600111 U03504 5p13 (glutamate) Solute carrier family 1, member 4/SLC1A4
600229 NM_003038 2p15-p13 (glutamate) Solute carrier family 1, member 5/SLC1A5 (neutral 109190 AF105230
19q13.3 AA) Solute carrier family 1, member 6/SLC1A6 600637 NM_005071 ****** (glutamate) Solute carrier family 2,
member 1/SLC2A1/SGLT1 182380 NM_006516 22q13.1 (glucose) Solute carrier family 2, member 2/SLC2A2/GLUT2
138160 NM_006516 3q26.1- (glucose) q26.3 Solute carrier family 2, member 3/SLC2A3/GLUT3 138170 M20681
12p13.3 (glucose) Solute carrier family 2, member 4/SLC2A4/GLUT4 138190 ****** 17p13 (glucose) Solute carrier family
2, member 5/SLC2A5/GLUT5 138230 NM_003039 1p36.2 (glucose) Solute carrier family 3 member 1/SLC3A1 (aa
104614 ****** 2p16.3 transporter) Solute carrier family 5 member 1/SLC5A2 (glucose) 182381 ****** 16p11.2 Solute
carrier family 5 member 3/SLC5A3 600444 L38500 21q22 Solute carrier family 5 member 6/SLC5A6 (folate, 604024
****** 2p23 biotin, lipoate) Solute carrier family 6 member 1/SLC6A1 (GABA) 137165 X54673 3p25-p24 Solute carrier
family 6 member 2/SLC6A2 163970 NM_001043 16q12.2 (noradrenalin) Solute carrier family 6 member 3/SLC6A3
126455 L24178 5p15.3 (dopamine) Solute carrier family 6 member 4/SLC6A4 182138 X70697 17q11.1- (serotonin) q12
Solute carrier family 6, member 5/SLC6A5 (glycine) 604159 NM_004211 ****** Solute carrier family 6, member
6/SLC6A6 (taurine) 186854 U16120 3p25-q24 Solute carrier family 6, member 8/SLC6A8 (creatine) 300036 NM_005629
300036 Solute carrier family 6, member 9/SLC6A9 (glycine) 601019 S70612 1p313 Solute carrier family 6, member
10/SLC6A10 601294 ****** 16p11.2 (creatine-testis) Solute carrier family 6, member 12/SLC6A12 603080 NM_003044
12p13 (GABA-betaine) Solute carrier family 7, member 1/SLC7A1 (cationic 104615 ****** 13q12.3 AA) Solute carrier
family 7, member 2/SLC7A2 (cationic 601872 D29990 8p22 AA) Solute carrier family 7, member 4/SLC7A4 (cationic
603752 ****** 22q11.2 AA) Solute carrier family 7, member 5/SLC7A5 (neutral 600182 M80244 16q24.3 AA) Solute
carrier family 7, member 7/SLC7A7 (dibasic 603593 Y18474 14q11.2 AA) Solute carrier family 7, member 9/SLC7A9
(neutral 604144 ****** 19q13.1 AA) Solute carrier family 10, member 1/SLC10A1 182396 NM_003049 chr. 14
(taurocholate)
Solute carrier family 10, member 2/SLC10A2 601295 NM_000452 13q33 (taurocholate) Solute carrier family 11, member
1/SLC11A1 (?) 600266 AH002806 2q35 Solute carrier family 11, member 2/SLC11A2 (iron) 600523 L37347 12q13
Solute carrier family 13, member 2/SLC13A2 604148 NM_003984 17p11.1- (dicarboxylic acids) q11.1 Solute carrier family
14, member 1/SLC14A1 (urea) 111000 ****** 18q11- q12 Solute carrier family 14, member 2/SLC14A2 (urea) 601611
X96969 18q12.1- q21.1 Solute carrier family 15, member 1/SLC15A1 600544 U13173 13q33- (peptides) q34 Solute
carrier family 15, member 2/SLC15A2 602339 S78203 ****** (peptides) Solute carrier family 16, member 1/SLC16A1
600682 NM_003051 1p13.2- (monocarboxylic acids) p12 Solute carrier family 16, member 2/SLC16A2 300095
NM_006517 Xq13.2 (monocarboxylic acids) Solute carrier family 16, member 3/SLC16A3 603877 NM_004207 ******
(monocarboxylic acids) Solute carrier family 16, member 4/SLC16A4 603878 ****** ****** (monocarboxylic acids)
Solute carrier family 16, member 5/SLC16A5 603879 NM_004695 ****** (monocarboxylic acids) Solute carrier family 16,
member 6/SLC16A6 603880 NM_004694 ****** (monocarboxylic acids) Solute carrier family 16, member 7/SLC16A7
603654 AF049608 12q13 (monocarboxylic acids) Solute carrier family 18, member 1/VAT1/SLC18A1 193001 L09118
10q25 (monoamines) Solute carrier family 18, member 2/VAT2/SLC18A2 193002 ****** 8p21.3 (monoamines) Solute
carrier family 18, member 3/VAT3/SLC18A3 600336 NM_003055 10q11.2 (monoamines) Solute carrier family 19, member
1/SLC19A1 600424 U19720 21q22.3 (reduced folate) Solute carrier family 19, member 2/SLC19A2 603941 AF160186
1q23.2- (thiamine) q23.3 Solute carrier family 21, member 2/SLC21A2 601460 NM_005630 3q21 (prostaglandin) Solute
carrier family 21, member 3/SLC21A3 602883 NM_005075 12p12 (organic anion) Solute carrier family 22, member
1/SLC22A1 602607 NM_003058 6q26 (organic cation) Solute carrier family 22, member 1-like/SLC22A1L 602631
AF037064 11p15.5 (organic cation) Solute carrier family 22, member 2/SLC22A2 602608 NM_003058 6q26 (organic
cation) Solute carrier family 22, member 4/SLC22A4 604190 NM_003059 Chr. 5 (organic cation) Solute carrier family 22,
member 5/SLC22A5 603377 NM_003060 5q33.1 (camitine) Solute carrier family 25, member 1/SLC25A1 190315
X96924 22q11 (tricarboxylic acids) (mitochondrial) Solute carrier family 25, member 11/SLC25A11 604165 NM_003562
17p13.3 (oxoglutarate/malate) (mitochondrial) Solute carrier family 25, member 12/SLC25A12 (?) 603667 NM_003705
****** (mitochondrial) Solute carrier family 25, member 13/SLC25A13 (?) 603859 ****** 7q21.3 (mitochondrial) Solute
carrier family 25, member 15/SLC25A15 603861 ****** 13q14 (ornithine) (mitochondrial) Solute carrier family 25, member
16/SLC25A16 139080 M31659 10q21.3- (ADP/ATP) (mitochondrial) q22.1 Solute carrier family 29, member
1/SLC29A1/ENT1 602193 NM_004955 6p21.2- (nucleoside) (mitochondrial) p21.1 Solute carrier family 29, member
2/SLC29A2/ENT2 602110 X86681 11q13 (nucleoside) (mitochondrial) Phase I Drug Monooxigenases Flavin-
Flavin-containing monooxygenase 1/FMO1 136130 NM_002021 1q23-q25 Metabolism (mixed function containing
Flavin-containing monooxygenase 3/FMO3 136132 AH006707 1q23-q25 (oxidation and oxidases) Mono- Flavin-containing
monooxygenase 4/FMO4 136131 NM_001460 1q23-q25 reduction) oxygenases Flavin-containing monooxygenase 5/FMO5
603957 NM_001461 1q21.1 P450 Aryl hydrocarbon receptor nuclear 126110 NM_001668 1q21 Cytochromes
translocator/ARNT Aryl hydrocarbon receptor nuclear translocator- 602550 NM_001178 11p15 like/ARNTL Aryl
hydrocarbon receptor/AHR 600253 NM_001621 7p15 Nuclear receptor subfamily 1, group I, member 603065
NM_003889 ****** 2/NR1I2 Constitutive androstane receptor, beta/orphan nuclear 603881 NM_005122 ******
hormone receptor/CAR Nuclear receptor subfamily 1, group H, member 600380 U07132 19q13.3 2/NR1H2 Retinoic acid
receptor, alpha/RARA 180240 NM_000964 17q12 Retinoic acid receptor, beta/RARB 180220 NM_000965 3p24 Retinoic
acid receptor, gamma/RARG 180190 M57707 12q13 Retinoid X receptor alpha/RXRA 180245 NM_005693 9q34.3
Retinoid X receptor beta/RXRB 180246 X66424 6p21.3 Retinoid X receptor gamma/RXRG 180247 U38480 1q22-q23
RAR-related orphan receptor A/RORA 600825 NM_002943 15q21- q22 RAR-related orphan receptor B/RORB 600825
****** 15q21- q22 RAR-related orphan receptor C/RORC 602943 NM_005060 1q21 cellular retinoic acid-binding
protein, type 180231 ****** 1q21.3 2/CRABP2 glucocorticoid receptor/GRL 138040 NM_000176 5q31 Peroxisome
proliferative activated receptor, 170998 NM_005036 22q12- alpha/PPARA q13.1 Peroxisome proliferative activated
receptor, 601487 NM_005037 3p25 gamma/PPARG Peroxisome proliferative activated receptor, 600409 NM_006238
1q21.3 delta/PPARD cytochrome P450, subfamily I, polypeptide 1 (aryl 108330 NM_000499 15q22- hydrocarbon
oxidase)/CYP1A1 q24 cytochrome P450, subfamily I, polypeptide 2 124060 AH002667 15q22- (phenacetin
metabolism)/CYP1A2 qter cytochrome P450, subfamily IB, polypeptide 1 601771 NM_000104 2p22-p21 (dioxin
inducible)/CYP1B1 cytochrome P450, subfamily II, polypeptide 1 123960 X13897 19q13.2 (phenobarbital
inducible)/CYP2A cytochrome P450, subfamily IIA, polypeptide 6 122720 NM_000762 19q13.2
(coumarin-7-hydroxylase)/CYP2A6 cytochrome P450, subfamily IIB (phenobarbital 123930 M29874 19q13.2
inducible)/CYP2B cytochrome P450, subfamily IIC, polypeptide 601129 ****** 10q24 8/CYP2C8 cytochrome P450,
subfamily IIC, polypeptide 9 601130 ****** 10q24 (hydroxylation of tolbutamide)/CYP2C9 Cytochromescytochrome P450,
subfamily IIC, polypeptide 601131 ****** 10q25 18/CYP2C18 cytochrome P450, subfamily IIC, polypeptide 19 124020
NM_000769 10q24.1- (mephenytoin 4-hydroxylase)/CYP2C19 q24.3 cytochrome P450, subfamily IID, polypeptide 6
124030 NM_000106 22q13.1 (debrisoquine hydroxylation)/CYP2D6 cytochrome P450, subfamily IIE (ethanol 124040
J02843 10q24.3- inducible)/CYP2E qter cytochrome P450, subfamily IIF (ethoxycoumarin 124070 NM_000774 19q13.2
monooxygenase), polypeptide 1/CYP2F1 cytochrome P450, subfamily IIJ (arachidonate 601258 NM_000775 1p31.3-
epoxygenase), polypeptide 2/CYP2J2 p31.2 cytochrome P450, subfamily IIIA (niphedipine 124010 NM_000776 7q22.1
oxidase), polypeptide 3/CYP3A3 cytochrome P450, subfamily IVA (fatty acid W- 601310 NM_000778 Chr.1 hydroxylase),
polypeptide 11/CYP4A11 cytochrome P450, subfamily IVB, polypeptide 124075 NM_000779 1p34-p12 1/CYP4B1
cytochrome P450, subfamily IVF (leukotriene B4-W- 601270 NM_000896 19p13.2
hydroxylase), polypeptide 3/CYP4F3 cytochrome P450, subfamily VIIA (cholesterol 7-a- 118455 M89803 8q11-q12
hydroxylase), polypeptide 1/CYP7A1 cytochrome P450, subfamily VIIB (oxysterol 7-a- 603711 AF029403 8q21.3
hydroxylase), polypeptide 1/CYP7B1 cytochrome P450, subfamily VIIIB (sterol 12-a- 602172 ****** 3p21.3-
hydroxylase), polypeptide 1/CYP8B1 p22 cytochrome P450, subfamily XIA (cholesterol side- 118485 NM_000781 15q23-
chain cleavage)/CYP11A q24 cytochrome P450, subfamily XIB, polypeptide 2 124080 NM_000498 8q21 (steroid
11-b-hydroxylase)/CYP11B2 cytochrome P450, subfamily XIX (androgen 107910 NM_000103 15q21.1
aromatase)/CYP19 cytochrome P450, subfamily XXI (sterol 21-a- 201910 M13936 6p21.3 hydroxylase)/CYP21
cytochrome P450, subfamily XXIV (25- 600125 S67623 20q13.2- hydroxyvitamin D24-hydroxylase)/CYP24 q13.3
cytochrome P450, subfamily XXVIA, polypeptide 1 602239 NM_000783 10q23- (retinoic acid hydroxylase)/CYP26A1
q24 cytochrome P450, subfamily XXVIIA, polypeptide 1 213700 NM_000105 2q33-qter (25-hydroxyvitamin
D-1-a-hydroxylase)/CYP27A1 adrenodoxin/ferredoxin 1/FDX1/ADX 103260 NM_004109 11q22 adrenodoxin
reductase/ferredoxin:NADP(+) 103270 NM_004110 17q24- reductase/FDXR/ADXR q25 cytochrome P450, subfamily
XXVIIB, polypeptide 1 264700 NM_000785 12q14 (25-hydroxyvitamin D-1-a-hydroxylase)/CYP27B1 cytochrome P450,
subfamily XLVI (cholesterol 24- 604087 NM_006668 14q32.1 hydroxylase)/CYP46 cytochrome P450, subfamily LI
(lanosterol 14-a- 601637 U51692 7q21.2- demethylase)/CYP51 q21.3 General General Monoamine Oxidase A; MAOA
309850 M69226 Xp11.23 Oxidases Oxidases Monoamine Oxidase B; MAOB 309860 M69177 Xp11.23
Copper-containing amine oxidase/AOC3 603735 NM_003734 17q21 Xanthine dehydrogenase/XDH 278300 NM_000379
2p23-p22 tryptophan 2,3-dioxygenase/TDO2 191070 NM_005651 4q31-q32 sulfite oxidase/SUOX 272300 NM_000456
****** Dehydrogenases Cofactor molybdenum factor synthesis 1/MOCS1 603707 AJ224328 6p21.3 Synthesis
molybdenum factor synthesis 2/MOCS2 603708 ****** 5q11 Alcohol alcohol dehydrogenases 1, alpha subunit/ADH1
103700 NM_000667 4q22 Dehydrogenases alcohol dehydrogenases 2, beta subunit/ADH2 103720 NM_000668 4q22
alcohol dehydrogenases 3, gamma subunit/ADH3 103730 M12272 4q22 alcohol dehydrogenases 4/pi isozyme/ADH4
103740 M15943 4q22 alcohol dehydrogenases 5/chi isozyme/ADH5 103710 NM_000671 4q21-q25 alcohol
dehydrogenases 6/ADH6 103735 NM_000672 15q26 alcohol dehydrogenases 7/ADH7 600086 AH006682 4q23-q24
Aldehyde aldehyde dehydrogenase 1/ALDH1 (liver cytosol) 100640 AH002598 9q21 Dehydrogenases aldehyde
dehydrogenase 2/ALDH2 (liver 100650 K03001 12q24.2 mitochondria) aldehyde dehydrogenase 3/acetaldehyde 100660
M74542 17p11.2 dehydrogenase/ALDH3 (stomach) aldehyde dehydrogenase 5/acetaldehyde 100670 NM_000692 9p13
dehydrogenase/ALDH5 aldehyde dehydrogenase 5, member Al/succinic 271980 NM_001080 6p22 semialdehyde
dehydrogenase/ALDH5A1 aldehyde dehydrogenase 6/acetaldehyde 600463 NM_000693 15q26 dehydrogenase/ALDH6
aldehyde dehydrogenase 7/acetaldehyde 600466 NM_000694 11q13 dehydrogenase/ALDH7 aldehyde dehydrogenase
8/ALDH8 601917 NM_000695 chr. 11 aldehyde dehydrogenase 9/g-aminobutyraldehyde 602733 NM_000696 1q22-q23
dehydrogenase/ALDH9 aldehydedehydrogenase 10/ALDH10 270200 NM_000382 17p11.2 Dihydro- Dihydropyrimidine
dehydrogenase (5-fluoroacil 274270 U09178 1p22 pyrimidine detoxification) Dehydrogenase Fatty Acid .beta.- Peroxisome
Peroxisome proliferative activated receptor, 170998 NM_005036 22q12- Oxidation Proliferation alpha/PPARA q13.1
Peroxisome proliferative activated receptor, 601487 NM_005037 3p25 gamma/PPARG Peroxisome proliferative activated
receptor, 180231 NM_006238 1q21.3 delta/PPARD Peroxisome peroxisome biogenesis factor 1/PEX1 602136 AB008112
7g21-q22 Synthesis peroxisomal membrane protein 3 (35kD, Zeliweger 170993 NM_000318 8q21.1
syndrome)/PXMP3/PEX2 peroxisomal biogenesis factor 3/PEX3 603164 NM_003630 ****** peroxisomal biogenesis
factor 6/PEX6 601498 NM_000287 6p21.1 peroxisomal biogenesis factor 7/PEX7 601757 NM_000288 6q22-q24
peroxisomal biogenesis factor 10/PEX10 602859 ****** ****** peroxisomal biogenesis factor 11A/PEX11A 603866
NM_003847 ****** peroxisomal biogenesis factor 11B/PEX11B 603867 NM_003846 ****** peroxisomal biogenesis
factor 12/PEX12 601758 NM_000286 peroxisomal biogenesis factor 13/PEX13 601789 U71374 2p15 peroxisomal
biogenesis factor 14/PEX14 601791 ****** ****** peroxisomal farnesylated protein/PXF/peroxisomal 600279
NM_002857 1q22 biogenesis factor 19/PEX19 Coenzyme A Fatty acid CoA Ligase, long chain 1/FACL1 152425 ******
3q13 Ligases Fatty acid CoA Ligase, long chain 2/FACL2 152426 ****** 4q34-q35 Fatty acid CoA Ligase, long chain
3/FACL3 602371 NM_004457 2q34-q35 Fatty acid CoA Ligase, long chain 4/FACL4 300157 NM_004458 Xq22.3 Fatty
acid CoA Ligase, very long chain 1/FACVL1 603247 ****** 15q21.2 Oxidation Enoyl-CoA, hydratase/3-hydroxyacyl CoA
261515 NM_001966 3q27 dehydrogenase/EHHADH hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA 600890
NM_000182 2p23 thiolase/enoyl-CoA hydratase, alpha subunit/HADHA hydroxyacyl-CoA dehydrogenase/3-ketoacyl-CoA
143450 NM_000183 2p23 thiolase/enoyl-CoA hydratase, beta subunit/HADHB acyl-Coenzyme A oxidase 1/ACOX1
(peroxisomal) 264470 NM_004035 17q25 acyl-Coenzyme A oxidase 2, branched chain/ACOX2 601641 NM_003500
13pl4.13 (peroxisomal) acyl-Coenzyme A dehydrogenase, C-2 to C-3 short 201470 NM_000017 12q22- chain
precursor/ACADS (mitochondrial) qter acyl-Coenzyme A dehydrogenase, C-4 to C-12 201450 NM_000016 1p31 straight
chain/ACADM (mitochondrial) acyl-Coenzyme A dehydrogenase, long 201460 NM_001608 2q34-q35 chain/ACADL
(mitochondrial) hydroxyacyl-Coenzyme A dehydrogenase, type 602057 NM_004493 ****** II/HADH2 enoyl-Coenzyme A
hydratase 1/ECH1 (peroxisomal) 600696 NM_001398 19q13 Reduction Aldo-Keto Aldo-keto reductase family 1, member
103830 NM_006066 1p33-p32 Reductases A1/dihydrodiol dehydrogenase/AKR1A1 Aldo-keto reductase family 1, member
600449 NM_001353 10p15- C1/dihydrodiol dehydrogenase/AKR1C1 p14 Aldo-keto reductase family 1, member 603966
NM_003739 10p15- C3/dihydrodiol dehydrogenase/AKR1C3 p14 Aldo-keto reductase family 1, member 600451 ******
10p15- C4/chlorodecone reductase/AKR1C4 p14 Aldo-keto reductase family 7, member A2/aflatoxin 603418 NM_003689
****** aldehyde reductase/AKR7A2 Carbonyl reductase 1/CBR1 114830 NM_001757 21q22.12 Carbonyl reductase
2/CBR2 ****** ****** chr. 11 Carbonyl reductase 3/CBR3 603608 NM_001236 21q22.2 Sepiapterin reductase
(7,8-dihydrobiopterin:NADP+ 182125 NM_003124 2p14-p12 oxidoreductase)/SPR Quinone Z-crystallin/quinone
reductase/CRYZ 123691 L315211 p31-p22 Oxidoreductases Z-crystallin-like/quinone reductase-like/CRYZL1 603920
NM_005111 21q22.1 NAD(P)H menadione oxidoreductase 1, dioxin- 125860 NM_000903 16q22.1
inducible/NMOR1/diaphorase 4/DIA4 NAD(P)H menadione oxidoreductase 2, dioxin- 160998 NM_000904 6pter-q12
inducible/NMOR2 Conjugation Sulfate Unit 3-prime-phosphoadenosine 5-prime-phosphosulfate 603262 NM_005443 4q
Activation synthase 1/PAPSS1 Phenol-preferring sulfotransferase, family 1A, 171150 NM_001055 16p12.1- member
1/SULT1A1 p11.2 Phenol-preferring sulfotransferase, family 1A, 601292 NM_001054 16p12.1- member 2/SULT1A2
p11.2 Phenol-preferring sulfotransferase, family 1A, 600641 L19956 16p11.2 member 3/SULT1A3 Sulfotransferase, family
1C, member 3/SULT1C1 602385 U66036 2q11.1- q11.2 Dehydroepiandrosterone (DHEA)-preferring 125263
NM_003167 19q13.3 sulfotransferase, family 2A, member 1/SULT2A1 Sulfotransferase, family 2B, member 1/SULT2B1
604125 NM_004605 19q13.3 Estrogen-preferring sulfotransferase/STE 600043 NM_005420 4q13.1
N-deacetylase/N-sulfotransferase (heparan 600853 U18918 5q32- glucosaminyl)/NDST1 q33.3
N-deacetylase/N-sulfotransfer- ase (heparan 603268 NM_003635 10q22 glucosaminyl)/NDST2
N-deacetylase/N-sulfotransferase (heparan 603950 NM_004784 ****** glucosaminyl)/NDST3 Carbohydrate
sulfotransferase 1 (chondroitin 603797 NM_003654 11p11.2- 6/keratan)/CHST1 p11.1 Carbohydrate sulfotransferase 2
(chondroitin 603798 ****** 7q31 6/keratan)/CHST2 Carbohydrate sulfotransferase 3 (chondroitin 603799 NM_004273
****** 6/keratan)/CHST3 Cerebroside sulfotransferase (3'- 602300 NM_004861 ******
phosphoadenylylsulfate:galactosylceramide 3')/CST Heparan sulfate (glucosamine) 3-O-sulfotransferase 603244 NM_005114
****** 1/HS3ST1 Heparan sulfate (glucosamine) 3-O-sulfotransferase 604056 NM_006043 16p12 2/HS3ST2 Heparan
sulfate (glucosamine) 3-O-sulfotransferase 604057 NM_006042 17p12- 3A1/HS3ST3A1 p11.2 Heparan sulfate
(glucosamine) 3-O-sulfotransferase 604058 NM_006041 17p12- 3B1/HS3ST3B1 p11.2 Heparan sulfate (glucosamine)
3-O-sulfotransferase 604059 AF105378 16p11.2 4/HS3ST4 Sulfhydrylation Methylguanine methyltransferase
(O6-alkylguanine 156569 M29971 10q26
detoxification) thiosulfate thiotransferase/rhodanese/TST (cyanide 180370 D87292 22q11.2- detoxification) qter UDP- UDP
glycosyltransferase 1/UGT1 191740 NM_001072 Chr. 12 Glycosyltransfer UDP glycosyltransferase family 2, member
600067 NM_001073 4q13 ases B4/UGT2B4 UDP glycosyltransferase family 2, member 600068 NM_001074 1q14
B7/UGT2B7 UDP glycosyltransferase family 2, member 600070 NM_001075 ****** B10/UGT2B10 UDP
glycosyltransferase family 2, member 600069 U06641 4q13 B15/UGT2B15 UDP glycosyltransferase family 2, member
601903 NM_001077 1q14 B17/UGT2B17 UDP glycosyltransferase 8/UGT8 601291 U30930 4q26
UDP-glucuronosyltransferase 218800 AJ005162 Chr.2 Carbon Unit methionine adenosyltransferase I, alpha/MAT1A 250850
NM_000429 10q22 Activation for methionine adenosyltransferase II, alpha/MAT2A 601468 NM_005911 2p11.2 SAM
Carbon Unit Folate Receptor Alpha/FOLR1 136430 M28099 11q13.3- Activation for g13.5 Folate Folate Receptor
Beta/FOLR2 136425 AF000380 11q13.3- q13.5 Folate Receptor Gamma/FOLR3 602469 Z32564 ****** Folate
Transporter (SLC19A1) 600424 U19720 21q22.3 Vitamin B12 binding protein 275350 NM_000355 22q11.2- qter
folylpolyglutamate synthetase/FPGS 136510 M98045 9cen-q34 gamma-glutamyl hydrolase/GGH 601509 U55206 ******
Methylenetetrahydrofolate reductase/MTHFR 236250 U09806 1p36.3 Dihydrofolate reductase/DHFR 126060 J00140
5q11.2- q13.2 5,10-methylenetetrahydrofolate dehydrogenase, 5,10- 172460 NM_005956 14q24 methylenetetrahydrofolate
cyclohydrolase, 10- formyltetrahydrofolate synthetase/MTHFD1 5,10-methenyltetrahydrofolate synthetase (5- 604197
NM_006441 Chr. 15 formyltetrahydrofolate cyclo-ligase)/MTHFS phosphoribosylglycinamide formyltransferase, 138440
NM_000819 21q22.1 phosphoribosylglycinamide synthetase, phosphoribosylaminoimidazole synthetase/GART folate
hydrolase 1/FOH1 600934 NP004467 11q14 6-pyruvoyl tetrahydrobiopterin synthase/PTPS 261640 Q03393 11q22.3-
q23.3 serine hydroxymethyltransferase 1 (soluble)/SHMT1 182144 NM_004169 17p11.2 senile hydroxymethyltransferase 2
138450 NM_005412 12q13 (mitochondrial)/SHMT2 Glycine aminotransferase/glycine cleavage T 238310 NM_000481
3p21.2- protein/GAT p21.1 5-methyltetrahydrofolate-homocysteine 156570 NM_000254 1q43 methyltransferase/methionine
synthase/MTR glutamate formiminotransferase/dihydrofolate 229100 ****** ****** synthetase Methylation
catechol-O-methyltransferase/COMT 116790 NM_000754 22q11.2 phenylethanolamine N-methyltransferase/PNMT
171190 NM_002686 17q21- q22 nicotinamide N-methyltransferase/NNMT 600008 NM_006169 11q23.1 Thiopurine
methyltransferase (6-mercaptopurine 187680 U12387 6p22.3 detoxification) Carbon Unit pyruvate dehydrogenase E1-alpha
subunit/PDHA1 312170 L48690 Xp22.2- Activation for p22.1 Acetyl-CoA pyruvate dehydrogenase (lipoamide) beta/PDHB
179060 NM_000925 3p13-q23 Acetyl-CoA pyruvate dehydrogenase complex, lipoyl- 245349 NM_003477 11p13
containing component X/E3-binding protein/PDX1 pyruvate dehydrogenase complex E3 subunit/DLD 246900 NM_000108
7q31-q32 Acylation sterol-O-acyl transferase 1/SOAT1 102642 L21934 1q25 sterol-O-acyl transferase 2/SOAT2 601311
****** chr. 12 N-acetyltransferase 1/arylamide acetylase 1/NAT1 108345 NM_000662 8p23.1- p21.3 N-acetyltransferase
2/arylamide acetylase 2/NAT2 243400 NM_000015 8p23.1- p21.3 Glutathione Glutathione-S-transferase 6 138391 ******
****** Transferase Glutathione-S-transferase, alpha 1/GSTA1 138359 L13269 6p12.2 Glutathione-S-transferase, alpha
2/GSTA2 138360 M15872 6p12.2 Glutathione-S-transferase, kappa 1/GSTK1 602321 ****** ******
Glutathione-S-transferase 1/MGST1 (microsomal) 138330 AH003674 Chr. 12 Glutathione-S-transferase 2/MGST2
(microsomal) 601733 NM_002413 4q28-q31 Glutathione-S-transferase, mu 1-like/GSTM1L 138270 ****** Chr. 3
Glutathione-S-transferase, mu 1/GSTM1 138350 J03817 1p13.3 Glutathione-S-transferase, mu 2/GSTM2 (muscle) 138380
NM_000848 1p13.3 Glutathione-S-transferase, mu 3/GSTM3 (brain) 138390 NM_000849 1p13.3
Glutathione-S-transferase, mu 4/GSTM4 138333 NM_000850 1p13.3 Glutathione-S-transferase, mu 5/GSTM5 (brain/lung)
138385 NM_000851 1p13.3 Glutathione-S-transferase, pi/GSTP1 134660 NM_000852 11q13 Glutathione-S-transferase,
theta 1/GSTT1 600436 NM_000853 22q11.2 Glutathione-S-transferase, theta 2/GSTT2 600437 NM_000854 22q11.3
Glutathione-S-transferase, zeta 1 /maleylacctoactetate 603758 NM_001513 14q24.3 isomerase/MAAI/GSTZ1
.gamma.-Glutamyl- Gamma-glutamyltranspeptidase 1/GGT1 231950 J04131 22q11.1- transpeptidase q11.2
Gamma-glutamyltranspeptidase 2/GGT2 137181 AH002728 22q11.1 Gamma-glutamyltransferase-like activity 1/GGTLA1
137168 NM_004121 ****** Catabolism Esterases paraoxonase 1/PON1 (arylesterase) 168820 AH004193 7q21.3
paraoxonase 2/PON2 602447 L48513 7q21.3 paraoxonase 3/PON3 602720 ****** 7q21.4 esterase C/ESC (acetyl
esterase) 133270 esterase A4/ESA4 133220 ****** 11q13- q22 esterase B/buteryl esterase/ESB (erythrocyte) 133260
****** ****** esterase B3/ESB3 133290 ****** Chr. 16 esterase A5/A7/acetylesterase/ESA5/ESA7 (brain) 133230
****** ****** acetylcholinesterase/ACHE 100740 M55040 7q22 butyrylcholinesterase 1/serum cholinesterase 177400
NM_000055 3q26.1- 1/BCHE1 q26.2 butyrylcholinestarase 2/serum cholinesterase 177500 ****** 2q33-q35 2/BCHE2
carboxylesterase 1/serine esterase/CES1 (hepatic) 114835 SEG_HUM 16q13- CESTG q22.1 arylacetamide
deacetylase/AADAC 600338 NM_001086 3q21.3- q25.2 Thioesterase acyl-CoA thioester hydrolase 1, long
chain/acyl-CoA 602586 ****** ****** thioesterase 1/ACT1 acyl-CoA thioester hydrolase 2, long chain/acyl-CoA 602587
****** ****** thioesterase 2/ACT2 esterase D/S-forinylglutathion hydrolase/ESC 133280 M13450 13q14.11
(thioesterase) Amidase aminoacylase 1/ACY1 104620 NM_000666 3p21.1 laminoacylase 2/ACY2/aspartoacylase (Canavan
271900 NM_000049 17pter- disease)/ASPA p13 fatty
acid amide hydrolase/FAAH 602935 NM_001441 1p34-p35 Epoxide epoxide hydrolase 1/EPHX1 (microsomal) 132810
NM_000120 1p11-qter Hydratases epoxide hydrolase 2/EPHX2 (cytosolic) 1132811 ****** 8p21-p12 |
