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Biotech / Medical : Biotech Valuation

CRSP 54.18

+3.2%

2:51 PM EST

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To: Biomaven who wrote (5522)	1/22/2002 4:16:48 PM
From: NeuroInvestment	Read Replies (2) of 52153

Peter: This is the third CNS program in the past few years (off the top of my head) I have seen run into Phase II immunoreactivity issues after passing Phase I satisfactorily. NeuroSearch's NS2710 anxiolytic and Neurocrine's APL for MS both had trials suspended in 1999 due to possible immune reactions, skin rashes in both cases. Both programs were dumped by their partners (Pharmacia and Novartis respectively), and have yet to resume Phase II, almost three years later, even though neither company believes the drug to be at fault. It is hard to prove the negative, unless they find some smoking gun viral culprit. What I am hearing fits your second scenario, that the desired autoimmune reaction--in some people at some doses--in itself is accompanied by inflammation. And if you cannot parse the two, AN-1792 would be doomed. Harry Tracy NeuroInvestment www.neuroinvestment.com

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