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To: axial who wrote (8550)	1/28/2002 3:09:44 PM
From: Mark Bartlett	Read Replies (3) of 14101

Jim, << I (personally) do not believe that such a large P3 could have phenomenal results without some "leakage" ->> The fact that these studies were done over so many centers makes it much more difficult for any one group to truly know the results. In any one group there may only be 8-10 participants of which only 4-5 are getting WF10. No research trial participant is going to stick there necks out and draw any conclusions from such a small sample size. As far as "large P3 studies" go, while this sample is fine for HIV trials, in fact the sample size for P3 trials in general is actually very small. Many P3s are in the many thousands of participants. Finally, I think most people are looking to the big pharmas for the next HIV breakthrough -- nobody will pay any attention to WF10 and companies like DMX until the the FDA (or similar) gives their research the stamp of approval. MB

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