Heading back to the bunker,...after this (gggggggg)
As far as kicking DMX, those are your words, I prefer discussing. I wish someone would have discussed with me the things that could go wrong with many of the stocks I have lost money in over the years,...that's not kicking in my mind, and it's not what happens on any thread I've been on lately where sharp edges are dulled quickly. I might be worth more now by not jumping into so many stocks with both feet before opening my eyes and seeing potential warning signs. I'm sure DMX is well aware of these concerns, and knew when they started this that there was considerable resistance from the FDA and the medical community to widespread, frequent use of DMSO in living organisms.
I wish DMX the best in their battle to prove to the world that Pennsaid works and works well with no side effects ever. But should we all walk down the garden path completely blind to potential problems,...physiologically, politically, and in a business context.
DMSO:
There is nothing in those articles I can presently see that counters my concerns. Actually the powerful effects this chemical displays on cell physiology worries me even more. As its mode of action and long term effects of frequent daily use are unknown. The FDA and the medical community have every right to be cautious with its use. Extreme incurable diseases such as Interstitial Cystitis with few treatments to relieve the symptoms are one thing, but caution is justified in proceeding to allow its use in the general public for less serious and painful illnesses that would require multiple exposures over long periods of time.
This chemical is a double edged sword, and has the potential to seriously disrupt cell function by changing membrane selective permeability, disrupting protein structure and function, and RNA structure and function by changing the properties of water around those molecules. The fact that these cell components can retain normal function after the DMSO is metabolized or diluted by diffusion, can be explained by the fact that living things can repair damage with time, and components like the membranes can return to normal once the DMSO is flushed from the system. But what if small amounts of DMSO are always present in the tissues, like what happens from daily, multi application use. And what about the dead cells of the outermost layer of the skin. Are the proteins and structure and function in those cells unchanged completely by DMSO's passage, or are the proteins altered, perhaps denatured irreversibly and their protective function impaired until new cells take their place. An Histologist may have the definitive answer, so far all we seem to have is theories,...mine included.
From your links on DMSO,...these are a few of the effects that concern me,....
Amstey and Parkman2 evaluated the influence of DMSO on the infectivity of viral nucleic acid, an indication of its transmembrane transport. It was found that DMSO enhanced polio RNA infectivity in kidney cells from monkeys. Enhancement occurred with all DMSO concentrations from 5 to 80% and was optimal at 40% DMSO, with a 20-minute absorption period at room temperature. A significant percentage of nucleic acid infection was absorbed within the first 2 minutes.
Cochran and his associates14 concluded that concentrations of DMSO below 20% did no influence the infectivity of tobacco mosaic virus (TMV) or the viral RNA. With concentrations between 20 and 60% the infectivity of TMV and TMV RNA varied inversely with the DMSO concentration.
Nadel and co-workers72 suggested that DMSO enhanced the penetration of the infectious agent in experimental leukemia of gunea pigs. Previously Schreck et al.97 had demonstrated that DMSO was more toxic in vitro to lymphocytic leukemia than to lymphocytes from normal patients.
Sulzberger and his co-workers107 evaluated the penetration of DMSO into human skin employing methylene blue, iodine, and iron dyes as visual tracers. Biopsies showed that the stratum corneum was completely stained with each tracer applied to the skin surface in DMSO. There was little or no staining below this layer. The authors concluded that DMSO carried substances rapidly and deeply into the horny layer and suggested the usefulness of DMSO as a vehicle for therapeutic agents in inflammatory dermatoses and superficial skin infections such as pyodermas.
DMSO in some instances will carry substances such as hydrocortisone or hexachlorophene into the deeper layers of the stratum corneum, producing a reservoir.104 This reservoir remains for 16 days and resists depletion by washing of the skin surface with soap, water, or alcohol.105
Gillchriest and Nelson37 have suggested that bacteriostasis from DMSO occurs due to a loss of RNA conformational structure required for protein synthesis.
Rosen and associates84 employed aqueous DMSO to alter the LD50 in rats and mice when oral quaternary ammonium salts were used as test compounds. In rats, the toxicity of pentolinium tartrate and hexamethonium bitartrate was increased by DMSO, while the toxicity of hexamethonium iodide was decreased.
Rosen and associates84 employed aqueous DMSO to alter the LD50 in rats and mice when oral quaternary ammonium salts were used as test compounds. In rats, the toxicity of pentolinium tartrate and hexamethonium bitartrate was increased by DMSO, while the toxicity of hexamethonium iodide was decreased.
Sams et al.90 studied the effects of DMSO on skeletal, smooth, and cardiac muscle, employing concentrations of 0.6-6%. DMSO strikingly depressed the response of the diaphragm to both direct (muscle) and indirect (nerve) electrical stimulation, and caused spontaneous skeletal muscle fasciculations. DMSO increased the response of the smooth muscle of the stomach to both muscle and nerve stimulations. The vagal threshold was lowered 50% by 6% DMSO. Cholinesterase inhibition could reasonably explain fasciculations of skeletal muscle, increased tone of smooth muscle, and the lower vagal threshold observed in these experiments. In vitro assays show that 0.8-8% DMSO inhibits bovine erythrocyte cholinesterase 16-18%.
Adamson and his co-workers1 applied DMSO to a 3-1 pedicle flap raised on the back of rats. The anticipated slough was decreased by 70%. The authors suggested that the primary action of DMSO on pedicle flap circulation was to provoke a histamine-like reponse. Roth87 has also evaluated the effects of DMSO on pedicle flap blood flow and survival, concluding that DMSO does indeed increase pedicle flap survival, but postulating that this increase takes place by some mechanism other than augmentation of perfusion. Kligman56, 57 had previously demonstrated that DMSO possesses potent histamine-liberating properties.
Deutsch23 has presented experimental data showing that 5% DMSO lessons the adhesiveness of blood platelets in vitro. Gorog39 has shown that DMSO is a good antagonist to platelet aggregation as well as thrombus formation in vivo. Gorog evaluated this in the hamster cheek pouch model. |
