Interesting link, with lots of stuff -
healthtech.com
(thanks Mike.)
(for example -
5:30 Antibody and Protein Arrays
Dr. Tara Heitner, Senior Scientist, Chip Technology, BioTrove Inc.
The Living Chip™ is an array of channels or throughholes (104-105) in a silicon wafer with a density comparable to standard microarray technologies but with the additional feature of isolated volumes (typically 10-100 nL in volume, 200-250 µm across, and at least 500 µm in length), each containing aqueous solutions or cells and media. At these small dimensions, fluid (containing reagents or cells) can easily be transferred into the channels and retained entirely by capillary forces due to surface functionalization. The absence of a bottom to the channels greatly simplifies reagent-loading, cherry-picking, washing steps and mixing that are currently performed in microtiter plates with complex robotics. The Living Chip™ has been applied to screening phage-display libraries in ultrahigh throughput. The advantage to performing screens in this platform are many; the most significant, however, is our ability to perform both affinity and functional screens in ultrahigh throughput and to perform several assays in parallel on the same clones. The ability to screen >106 phage clones/day in ultrahigh throughput for both affinity and functional assays will be demonstrated. This technology may be applied to all forms of display technology, many different types of assays, and combinatorial library storage...) |
