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Biotech / Medical : DYAX: Dyax Corp.

DYAX 38.41

0.0%

Jan 25 4:00 PM EST

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To: Mike McFarland who wrote (29)	2/13/2002 12:04:33 PM
From: nigel bates	of 197

Cheers, Mike. Some interesting stuff there - "...2:50 Yeast Display for Affinity Maturation of Human Fab Antibodies Dr. Simon E. Hufton, Director of Research, Dyax SA The rapid and efficient affinity maturation of biomolecules is a critical component of the drug development pipeline. Selection of yeast-displayed repertoires by fluorescent-activated cell sorting has proven an effective method for the affinity maturation of scFv antibodies. We present the affinity maturation of human Fab antibodies by similar selection of yeast-displayed repertoires. Furthermore, the use of the yeast mating life cycle to generate combinatorial diversity will be presented, and application to both affinity maturation and the generation of large naïve antibody repertoires will be discussed..."

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