rec'd from a friend (thanks, J!) who can't post here.....
Journal of Virology, March 2002, p. 3045-3048, Vol.
76, No. 6 Copyright © 2002, American Society for
Microbiology. All Rights Reserved.
Porcine Endogenous Retrovirus Transmission
Characteristics of an Inbred Herd of Miniature Swine
*** Beth A. Oldmixon,1 James C. Wood,1 Thomas A.
Ericsson,1 Carolyn A. Wilson,2 Mary E. White-Scharf,3
Goran Andersson,3 Julia L. Greenstein,1 Henk-Jan
Schuurman,1 and Clive Patience1,3*
Immerge BioTherapeutics, Inc.,1 BioTransplant, Inc.,
Charlestown, Massachusetts,3 Division of Cellular and
Gene Therapies, Center for Biologics Evaluation and
Research, Federal Drug Administration, Bethesda,
Maryland2
Received 1 October 2001/ Accepted 19 December 2001
Here we report the identification of inbred miniature
swine that failed to produce human-tropic
replication-competent porcine endogenous retroviruses
(HTRC PERVs), using in vitro coculture assays. When
HTRC PERVs were isolated from transmitting animals,
all were recombinant viruses, with the
receptor-binding domain of PERV-A combining with
PERV-C-related sequences. |
