>> Why one should not try anti-CD2/anti-TNF combination? <<
Because it makes little sense. If the effector cell is gone, you won't need anti-"effector cell product".
>> So far "new biologic" show only 30-35% response rate <<
If you look at the highest sq and i.v. doses in those small phase II trials, 507 yielded about 40% PASI 75. As you know, it's an extremely potent treatment. Either it will work or it won't. If it does, (1) it should obviate the need for anti-TNF, and (2) I believe that responses would improve with time.
If you take anti-TNF and encounter Listeria (or a variety of other bugs), I believe that you stand an increased chance of dying. If you specifically tolerize/remove the population of T cells that is mediating an autoimmune disease, you've done no harm AND you've removed the cells that were producing the TNF, IL-1, etc.
The story is still out, and medicines replace good medicines. I have great respect for Enbrel, more all the time.
(thanks Sales!)
Rick |
