Brudda Pat -
Just re-read my post, trying to see what you were getting at. My meaning certainly wasn't clear.
As it happens, research into DMSO, and Fungoff has lead to the most amazing collection of links.
You are right to re-emphasize the additional properties of DMSO.
"I guess my questions about the use of DMSO in Pennsaid work the other side of the coin that russett takes. Are there not intrinsically worthwhile benefits in Pennsaid, derived from its use of DMSO, that go beyond pain killing?"
One of the things I wondered about was whether there wasn't a synergy between doclofenac and DMSO: that is, until the microtubules deliver diclofenac to the area, perhaps some of the initial relief is from DMSO, itself.
As regards the patented process, I recall both Mark and di7026 have commented on aspects of pharma patents; they differ from the patents we have discussed in the past. I'll try to search for di7026's comments on SH, which is down now.
But I did some research into microtubule transport, which was a pretty interesting little voyage...
Message 16958856
...and discovered that microtubule transport occurs outside the microtubule, not inside !
stolaf.edu
I'm only speculating here. I'm guessing that the proprietary (patented) part of Pennsaid lies in the agent that gets diclofenac into the vesicles after it has penetrated the cell membrane. It may also have an effect on "directionality" of transport.
I am guessing, therefore, that Pennsaid's effectiveness does not simply derive from undifferentiated transport by DMSO, but also involves another agent which facilitates vesicular encapsulation and therefore, transport.
Please be clear, Pat: this is only guesswork. I am not stating in any way that this is a fact.
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Researching Fungoff was another wonderful little trip.
To shorten the story, I ran into four non-prescription solutions for toe/foot fungus which appeared to predominate -
1 - Vinegar soaks (up to 6 months)
2 - Vicks Vaporub (up to 6 months)
3 - Standalone use of Tree oil (up to 3-4 months)
4 - Tree Oil with DMSO (about a month)
(Note: The camphorated smell in Vicks Vaporub and the similar smell in Tree Oil suggests to me that there is a common agent in both)
There was, of course, a whole list of prescribed treatments, many of them quite expensive. Some of them did not appear to work very well.
One poster stated that he had obtained really fast relief by sanding down the surface of the nail, to make it thinner, then using Tree Oil and DMSO.
Here's another...
"StephaniePlum...yes, tea tree oil is wonderful for toenail fungus, or fingernail fungus if you wear false nails. I mix some with DMSO and put it in a dropper bottle and put a drop on each toenail in a.m and p.m. Remember to have clean toes as DMSO takes anything on the skin "inside." It cured my toenail fungus in about 3 weeks."
roundtablearchives_w.tripod.com
Of course, there are also links where the ubiquitous MSM (DMSO restated) is the carrier.
wizardofeyez.com
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Some additional links...
create.org
skinsite.com
backcountry.net
bcn.net
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Finally, here's another of the many uses of DMSO - this was a new one!
"During The Bone Marrow Transplant:
A long-term IV catheter (kath-uh-ter) will be used to give you the bone marrow. You may need to have a "central line" put in if you do not have an IV catheter. This central line will be put into a large blood vessel near your collarbone or in your neck. The head of your bed may be lowered to help the blood vessel fill up. This may make it easier to put in the catheter. The skin where the catheter will be placed is numbed so you won't feel much pain.
The harvested bone marrow will be thawed. Caregivers will put it into your long-term catheter or central line using a syringe and needle. It may take about 30 minutes to give you the harvested bone marrow.
You may feel short of breath during the transplant because the bone marrow is put into the IV quickly. You may also feel nauseated (sick to your stomach) or vomit (throw up). This can be caused from a medicine called "DMSO". DMSO was put into your own bone marrow after it was harvested. This kept the bone marrow fresh until it was time to give it back to you. Caregivers may give you medicine before, during, or after the BMT to help lessen these side effects."
health.wchsys.org |
