SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Gold/Mining/Energy : Nuvo Research Inc
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: Montana Wildhack who wrote (9058)3/19/2002 9:23:40 AM
From: Cal Gary  Read Replies (1) of 14101
 
Hi Wolf. Thanks for the reference.

Check out another Di7026 message, especially item #4. I can't imagine there will be a lack of volunteers for a head to head marketing trials. In fact it may raise our public profile.

So what the odds of this happening??

SUBJECT: RE: fda re dmso/question for di7026/mb Posted By: di7026
Post Time: 3/16/02 15:30
« Previous Message Next Message »

You asked 'how many mg's of dmso would a 4 time a day pennsaid user rub on in the course of that day?'
First I have problems concerning the quantity they use on the site your sited. 50mg is about 50 microliter, or about 2 small drops with a micropipetter. That can't be the limit. It's a bit confusing. Anyhow here are some of my thoughts below:

I hope these following points would provide at least partial answers to your questions.

(1) Pennsaid contains 45.4% DMSO.

(2) Each Pennsaid application is probably around 1-2 ml (DMSO has a density of around 1, thus 1ml of DMSO=1gram) in volume depending on the size of the area. For 2 ml of Pennsaid, there is about 1 ml of DMSO.

(3) I don't know how much of DMSO is actually absorbed into circulation when applied topically. However, most absorbed DMSO is excreted quickly in the urine and does not stay in the blood. The amount recommended from your post is for effective blood concentrations, not for topical application in which only a small fraction is absorbed and even less stays in the blood for more than a few minutes.

(4) Ethanol is listed in the same category as DMSO. In a bottle of beer of 341 ml that contains 5% (v/v) of alcohol, there is 17 ml of ethanol in that very bottle. Drinking that bottle is equivalent to an intake of 17 ml of ethanol, while a 2 ml Pennsaid topical treatment would provide a fraction of the 1 ml of DMSO in Pennsaid (since only a fraction is absorbed)


stockhouse.com
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News