EP,
This abstract appears to be the one referenced, but was published in November '01. Adds only a little color to the PR:
>>Science 2001 Nov 9;294(5545):1343-6
A phosphatase associated with metastasis of colorectal cancer.
Saha S, Bardelli A, Buckhaults P, Velculescu VE, Rago C, St Croix B, Romans KE, Choti MA, Lengauer C, Kinzler KW, Vogelstein B.
Howard Hughes Medical Institute, The Oncology Center, Department of Surgery, Johns Hopkins Medical Institutions, Baltimore, MD 21231, USA.
To gain insights into the molecular basis for metastasis, we compared the global gene expression profile of metastatic colorectal cancer with that of primary cancers, benign colorectal tumors, and normal colorectal epithelium. Among the genes identified, the PRL-3 protein tyrosine phosphatase gene was of particular interest. It was expressed at high levels in each of 18 cancer metastases studied but at lower levels in nonmetastatic tumors and normal colorectal epithelium. In 3 of 12 metastases examined, multiple copies of the PRL-3 gene were found within a small amplicon located at chromosome 8q24.3. These data suggest that the PRL-3 gene is important for colorectal cancer metastasis and provide a new therapeutic target for these intractable lesions.<<
I'm trying to remember if Science is one of those that will let you look at the full articles for registering (as opposed to registering and paying). If so, I've probably got access, and will check it tomorrow. GZMO looks mighty cheap to me, but no SI biofreak has jumped on the bandwagon, and I can't say I know the company deeply.
Cheers, Tuck |
