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Biotech / Medical : HuMAB companies

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To: nigel bates who wrote (356)	4/9/2002 4:27:26 AM
From: Icebrg	Read Replies (1) of 1022

From Abbott's news release this morning: ABBOTT PARK, Ill., April 9 /PRNewswire-FirstCall/ -- Abbott Laboratories (NYSE: ABT - news) today announced that it has simultaneously submitted a Biologic License Application (BLA) to the U.S. Food and Drug Administration (FDA) and a Marketing Authorization Application (MAA) to the European Agency for the Evaluation of Medicinal Products (EMEA) seeking approval to market D2E7 (adalimumab, ay-da-lim-yoo-mab) for rheumatoid arthritis (RA). D2E7 is the first fully human monoclonal antibody to be developed. What is the origin of this mAb? As they are now filing for approval they must have had the mAb under development for quite some time. But I have not seen Abgenix or Medarex claiming responsibility for D2E7. So Abbott should have had another mAb-source. How did they do it? Ice

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