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Biotech / Medical : Cambridge Antibody Technology Group

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To: Jongmans who started this subject	4/11/2002 9:06:21 AM
From: nigel bates	of 625

Anyone in Massachusetts in a couple of week's time ? Cambridge Healthtech Institute's Recombinant Antibodies Conference (Apr 24-25) healthtech.com ...9:40 In Vitro Selection and Evolution in Antibody Drug Discovery Dr. Lutz Jermutus, Display Technology Development, Cambridge Antibody Technology Ribosome display is a powerful in vitro selection system that can be utilized in both the primary isolation and the evolution of antibody drug candidates. Data will be presented to illustrate how the technique has been used to generate cytokine-neutralizing antibodies. Primary selection strategies, directed evolution strategies, high-throughput screening data and results of cell-based assays demonstrating the biological activity of the in vitro selected antibodies will be explained. These examples will be used to highlight the various specific advantages of ribosome display as compared to other selection methods such as phage display or surface display. (Coauthors: Maria Groves, Ross Stewart, George Thom, Emma de Vries, Svava Wetzel)...

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