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Biotech / Medical : AVANT Immunotherapeutics Inc. (Nasdaq: AVAN)

AVAN 10.04

0.0%

Jun 12 9:41 AM EDT

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To: Harry Stover who started this subject	4/11/2002 11:29:30 AM
From: aknahow	of 513

Six months have gone by, so the booster shots have been administered. Not sure how often HDL is being measured but am sure it was measured prior to the booster. Even if still blinded, examination of the results of HDL measurement would show if the vaccine was working. An significant increase in HDL among subjects in the trials would be most likely seen as being due to the vaccine among the treated subjects. The question is has information begun to leak? From the 10K " These data were extremely helpful in moving the program forward to a placebo controlled Phase II study, which was initiated in August 2001, in approximately 200 patients with low levels of HDL cholesterol. The objectives of the study are to evaluate the safety, immunogenicity and dose-response relationship of the CETi-1 product in patients who receive an initial immunization followed by boosters. The primary endpoint is the change in HDL cholesterol measured after the six-month booster and results are expected from the trial during 2003. As clinical data become available, we plan to seek a corporate partner to complete development and to commercialize the CETi-1 vaccine."

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