Sepracor-Looks very promising Message Board

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Biotech / Medical : Sepracor-Looks very promising

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To: John Zwiener who wrote (211)	7/10/1997 2:13:00 AM
From: James Silverman	of 10280

John, Seldane and related antihistamines cause heart attacks via dangerous drug-drug interactions, this is not questionable. Also for clarification I dont think Seldane has been officially pulled from the market as of yet. The FDA issued a directive to do so and Hoechst (Seldane) and Ivax (generics) filed objections. I dont think this has been resolved yet but I need to check. Also Allegra is not a chiral drug but a safer active metabolite of Seldane. Your case for prescribing the chiral version over the racemic version is what SEPR is counting on via significantly smaller doses (1/4th) and hence lowered side effects. I just dont see the FDA pulling albuterol, I'd put the chances at less than 10%. Its going to take a lot of marketing and a lot of money to fully penetrate the MDI inhaler markets, not as simple as superior data. Habits are hard to change from both a patients standpoint as well as that from the prescribing doctor which is why the better drugs dont always win out. Of course they only need to penetrate a small portion of the inhaler markets to make ample amounts of money which is why I am a shareholder.

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