US6417176: Arylsulfonanilide phosphates
Country: US United States of America
Inventor: Houze, Jonathan B.; San Mateo, CA
15 pages
Assignee: Tularik, Inc., South San Francisco, CA
Published / Filed: July 9, 2002 / Feb. 7, 2001
Application Number: US2001000779419
Abstract: The invention provides compounds, compositions and methods relating to novel arylsulfonanilide derivatives and their use as pharmacologically active agents. The compositions find particular use as pharmacological agents in the treatment of disease states, particularly cancer, psoriasis, vascular restenosis, infections, atherosclerosis and hypercholesterolemia, or as lead compounds for the development of such agents.
Attorney, Agent or Firm: Townsend and Townsend and Crew LLP ;
Related Applications: Application Number ApplDate Patent Pub. Date Title
US2000000595398 2000-06-14 US6211167 2001-04-03 Arylsulfonanilide phosphates
US1999000336062 1999-06-18
Parent Case:
This application is a continuation of and claims benefit of U.S. application Ser. No. 09/595,398, filed Jun. 14, 2000 now patented, U.S. Pat. No. 6,211,167, which is a continuation of U.S. application Ser. No. 09/336,062 filed Jun. 18, 1999 now abandoned, which claims the benefit of U.S. Provisional Patent App. Ser. No. 60/090,681 filed Jun. 25, 1998.
First Claim:
What is claimed is:
1. A method of treating a disease state characterized by abnormally high levels of low density lipoprotein particles or cholesterol in the blood, which method comprises administering to a mammalian subject in need thereof a therapeutically effective amount of a composition comprising a compound of formula: [Figure] or a pharmaceutically acceptable salt thereof, wherein
R1 is a member selected from the group consisting of hydrogen, (C1 -C6)alkyl and (C1 -C6)heteroalkyl;
R2 and R3 are each independently selected from the group consisting of hydrogen, halogen, (C1 -C8)alkyl, (C1 -C8)heteroalkyl, --OR11 and --NR11 R12, wherein R11 and R12 are each independently selected from the group consisting of hydrogen, (C1 -C8)alkyl (C1 -C8)heteroalkyl; or
R2 and R3, when attached to adjacent carbon atoms, can be linked together to form a fused 5-, 6- or 7-membered ring;
R4 and R5 are each independently selected from the group consisting of hydrogen, (C1 -C8)alkyl, (C1 -C8)heteroalkyl, aryl, heteroaryl, aryl(C1 -C4)alkyl, aryl(C1 -C4) heteroalkyl, heteroaryl(C1 -C4)alkyl and heteroaryl(C1 -C4)heteroalkyl, and are optionally linked together to form a 5-, 6- or 7-membered ring; or
R4 represents a single bond to the phenyl ring bearing the phosphoryl group and R5 is selected from the group consisting of hydrogen, (C1 -C8)alkyl, (C1 -C8) heteroalkyl, aryl, heteroaryl, aryl(C1 -C4)alkyl, aryl(C1 -C4)heteroalkyl, heteroaryl(C1 -C4) alkyl and heteroaryl(C1 -C4)heteroalkyl; and
Ar is a substituted aryl group selected from the group consisting of: [Figure]
wherein
X1 and X2 are each independently selected from the group consisting of F, Cl and Br.
US6413728: Methods for detecting SODD genes and proteins
Country: US United States of America
Inventor: Goeddel, David V.; Hillsborough, CA
Jiang, Yingping; South San Francisco, CA
9 pages
Published / Filed: July 2, 2002 / Oct. 8, 1999
Application Number: US1999000416214
Abstract: The invention provides methods and compositions relating to Suppressor of Death Domain (SODD) proteins which regulate cellular signal transduction and transcriptional activation, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SODD encoding nucleic acids or purified from human cells. The invention provides isolated SODD hybridization probes and primers capable of specifically hybridizing with the disclosed SODD genes, SODD-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
Attorney, Agent or Firm: Osman, Richard Aron ;
Related Applications: Application Number ApplDate Patent Pub. Date Title
US1998000035676 1998-03-05
First Claim:
What is claimed is:
1. A method for detecting a SODD (Suppressor of Death Domain) polypeptide in a sample comprising the steps of:
(a) contacting a sample comprising a natural human SODD polypeptide with an agent which specifically binds the polypeptide, and
(b) detecting specific binding of the agent to the polypeptide as an indication of the presence of the polypeptide in the sample,
wherein the agent specifically binds a protein consisting of SEQ ID NO:2 and the agent is selected from the group consisting of an antibody, a T-cell receptor and a TNF receptor DR3 domain. |
