Circ Res 2002 Aug 23;91(4):278-80
Short-term treatment with ranolazine improves mechanical efficiency in dogs with chronic heart failure.
Chandler MP, Stanley WC, Morita H, Suzuki G, Roth BA, Blackburn B, Wolff A, Sabbah HN.
Department of Medicine (H.M., G.S., H.N.S.), Henry Ford Heart and Vascular Institute, Detroit, Mich.
The present study assesses whether ranolazine increases left ventricular (LV) function without an increase in myocardial oxygen consumption (MOV0312;O(2)) and thus improves LV mechanical efficiency in dogs with heart failure (HF). Ranolazine did not change MOV0312;O(2) and LV mechanical efficiency increased (22.4+/-2.8% to 30.9+/-3.4% (P<0.05). In contrast, dobutamine significantly increased MOV0312;O(2) and did not improve mechanical efficiency. Thus, short-term treatment with ranolazine improved LV function without an increase in MOV0312;O(2), resulting in an increased myocardial mechanical efficiency in dogs with HF. |
