United States Patent 6,437,113
Goeddel , et al. August 20, 2002
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Suppressors of death domains
Abstract
The invention provides methods and compositions relating to Suppressor of Death Domain (SODD) proteins which regulate cellular signal transduction and transcriptional activation, and related nucleic acids. The polypeptides may be produced recombinantly from transformed host cells from the disclosed SODD encoding nucleic acids or purified from human cells. The invention provides isolated SODD hybridization probes and primers capable of specifically hybridizing with the disclosed SODD genes, SODD-specific binding agents such as specific antibodies, and methods of making and using the subject compositions in diagnosis, therapy and in the biopharmaceutical industry.
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Inventors: Goeddel; David V. (Hillsborough, CA); Jiang; Yingping (South San Francisco, CA)
Assignee: Tularik Inc. (South San Francisco, CA)
Appl. No.: 035676
Filed: March 5, 1998
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Claims
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What is claimed is:
1. An isolated, recombinant polynucleotide comprising a coding region encoding a human SODD polypeptide which specifically binds an antibody which specifically binds a protein consisting of SEQ ID NO:2.
(snip, ten claims total) |
