NAPRO - EUROPEAN PATENT - DELIVERY OF TAXANES
Part 2 of 3 posts
Part 2:CLIAMS
Claims
What is claimed is:
1. A composition useful for treating a taxane-responsive disease condition, comprising a taxane and at least one compound selected from the group consisting of Vitamin E-TPGS, dimethylisosorbide (DMI), methoxy PEG 350, citric acid, PEG 300, and PEG 4600.
2. The composition of claim 1 comprising taxane and Vitamin E-TPGS.
3. The composition of claim 1 comprising about 65% to about 70% Vitamin E-TPGS, about 20% to about 25% DMI, and about 5% to about 10% taxane.
4. The composition of claim 3 further comprising citric acid.
5. The composition of claim I comprising ethanol, Vitamin E-TPGS, and taxane.
6. The composition of claim 5 comprising about 25% to about 75% Vitamin E-TPGS, about 25% to about 75% ethanol, and about 0.6% to about 5% taxane.
7. The composition of claim 6 further comprising about 0.2% citric acid.
8. The composition of claim 7 further comprising about 10% polyethoxylated castor oil.
9. The composition of claim 1 comprising polyethoxylated castor oil, citric acid, dimethylisosorbide, Vitamin E-TPGS, and taxane.
10. The composition of claim 9 comprising about 10% polyethoxylated castor oil, about 25% to about 30% dimethylisosorbide, about 50% to about 60% Vitamin E-TPGS, about 0.2% citric acid, and about 5% to about 10% taxane.
11. The composition of claim 1 wherein the taxane is paclitaxel or derivatives, analogues, or prodrugs thereof.
12. The composition of claim 1 comprising methoxy PEG 350, Vitamin E-TPGS, and taxane.
13. The composition of claim 12 comprising about 25% methoxy PEG 350, about 65%
Vitamin E-TPGS, and about 10% taxane.
14. The composition of claim 1 comprising PEG 300, Vitamin E-TPGS, and taxane.
15. The composition of claim 14 comprising about 25% PEG 300, about 65% Vitamin
E-TPGS, and about 10% taxane.
16. The composition of claim 1 comprising PEG 4600, dimethylisosorbide, Vitamin E-
TPGS, and taxane.
17. The composition of claim 16 comprising about 5% PEG 4600, about 25% dimethylisosorbide, about 70% Vitamin E-TPGS, and about 10% taxane.
18. A method of treating a taxane-responsive disease condition comprising the steps of :
obtaining a composition comprising a taxane and at least one compound selected from the group consisting of Vitamin E-TPGS, dimethylisosorbide, polyethoxylated castor oil, ethanol, methoxy PEG 350, citric acid, PEG 300, and PEG 4600; and
administering said composition to a mammal having a taxane-responsive disease condition.
19. The method of claim 18 wherein said composition comprises about 65% to about 70% Vitamin E-TPGS, about 20% to about 25% dimethylisosorbide, about 5% to about 10% taxane.
20. The method of claim 19 further comprising citric acid.
21. The method of claim 18 wherein said composition comprises about 25% to about 75% Vitamin E-TPGS, about 25% to about 75% ethanol, and about 0.6% to about 5% taxane; and wherein administering comprises intravenous or parenteral administration.
22. The method of claim 21 wherein the composition further comprises about 0.2% citric acid.
23. The method of claim 18 wherein said composition comprises about 10% polyethoxylated castor oil, about 25% to about 30% dimethylisosorbide, about 50% to about 60% Vitamin E-TPGS, and about 5% to about 10% taxane; and wherein administering said composition comprises oral administration.
24. The method of claim 18 wherein said composition comprises about 25% PEG 300, about 65% Vitamin E-TPGS, and about 10% taxane.
25. The method of claim 18 wherein said composition comprises about 5% PEG 4600, about 25% dimethylisosorbide, about 70% Vitamin E-TPGS, and about 10% taxane.
26. The method of claim 18 wherein said taxane-responsive disease condition is selected from the group consisting of ovarian cancer, prostate cancer, breast cancer, malignant lymphoma, lung cancer, melanoma, Kaposi's sarcoma, polycystic kidney disease, Alzheimer's disease, malaria, and rheumatoid arthritis
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John McCarthy |
