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Biotech / Medical : Targeted Gene Repair
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To: John McCarthy who started this subject9/15/2002 8:22:54 PM
From: John McCarthy   of 22
 
TARGETED GENE THERAPY

Subject:CD - (Cardiovascular diseases)
(The following material is presented in Ascending Date Order)

This post is generated by a program that reads a database and generates this file. Errors will result from incorrect database material. Updates to the database automatically reflected in this file.

Researcher Name shown is my estimate of Principal Researcher

DB Key:2001-CD-B
Doc:Abstract
Vector:RDO RNA-DNA chimeric oligonucleotide
Experiment:Failed or Not Applicable
Of Note:None

4/1/2001-----Dickson, George J., Ph.D.-----Royal Free and University College Medical School, London
Title:Gene correction of the apolipoprotein (Apo) E2 phenotype to wild-type ApoE3 by in situ chimeraplasty
Link:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11278248&dopt=Abstract

Snippet:
About one-third of apoE2 was converted to apoE3, and the repair was stable through 12 passages

DB Key:2001-CD-D
Doc:Abstract
Vector:RDO RNA-DNA chimeric oligonucleotide
Experiment:Failed or Not Applicable
Of Note:None

8/1/2001-----Dickson, George J., Ph.D.-----Royal Holloway-University of London
Title:Oligonucleotide-based gene correction strategies: applications to neuromuscular and cardiovascular diseases
Link:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=11471201&dopt=Abstract

Snippet:
Although the only gene defects that can be corrected by chimeraplasty are point mutations,

DB Key:2001-CD-E
Doc:Croatioan Medical Journal
Vector:RDO RNA-DNA chimeric oligonucleotide
Experiment:Failed or Not Applicable
Of Note:None

8/3/2001-----Dickson, George J., Ph.D.-----Royal Holloway-University of London
Title:Oligonucleotide-based gene correction strategies: applications to neuromuscular and cardiovascular diseases
Link:http://www.cmj.hr/2001/4204/cmj42(4)18.pdf
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