SI
SI
discoversearch

We've detected that you're using an ad content blocking browser plug-in or feature. Ads provide a critical source of revenue to the continued operation of Silicon Investor.  We ask that you disable ad blocking while on Silicon Investor in the best interests of our community.  If you are not using an ad blocker but are still receiving this message, make sure your browser's tracking protection is set to the 'standard' level.
Biotech / Medical : Targeted Gene Repair
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  
To: John McCarthy who started this subject9/15/2002 8:23:56 PM
From: John McCarthy   of 22
 
TARGETED GENE THERAPY

Subject:TFO - (Triple helix-forming oligonucleotide)
(The following material is presented in Ascending Date Order)

This post is generated by a program that reads a database and generates this file. Errors will result from incorrect database material. Updates to the database automatically reflected in this file.

Researcher Name shown is my estimate of Principal Researcher

DB Key:1993-TFO-A
Doc:Abstract
Vector:TFO Triple helix-forming oligonucleotide
Experiment:Failed or Not Applicable
Of Note:TFO

12/1/1993-----Havre PA-----Yale University School of Medicine
Title:Targeted mutagenesis of simian virus 40 DNA mediated by a triple helix-forming oligonucleotide
Link:http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=8230456&dopt=Abstract

Snippet:
In control experiments, no mutagenesis above the background frequency in the assay was produced by a non-triplex-forming, psoralen-linked oligonucleotide unless a vast excess of this oligonucleotide was used, demonstrating the specificity of the targeted mutagenesis.

DB Key:2002-TFO-A
Doc:Web Page Article
Vector:TFO Triple helix-forming oligonucleotide
Experiment:Failed or Not Applicable
Of Note:TFO

6/1/2002-----Stanojevic, D.-----MIT
Title:A highly potent artificial transcription factor
Link:http://www.wi.mit.edu/far/far_publications_2002_sv.html

Snippet:
The structure of this artificial transcription factor (ATF) consists of three parts: (i) triple-helix- forming oligonucleotide as a DNA-binding domain; (ii) composite linker moiety; and (iii) short synthetic peptide
Report TOU ViolationShare This Post
 Public ReplyPrvt ReplyMark as Last ReadFilePrevious 10Next 10PreviousNext  

HomeMailHotSubjectMarksPeopleMarksKeepersSettings
Terms Of UseContact UsCopyright/IP PolicyPrivacy PolicyAbout UsFAQAdvertise on SI
© 2025 Knight Sac Media.  Data provided by Twelve Data, Alpha Vantage, and CityFALCON News