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Biotech / Medical : Targeted Gene Repair
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To: John McCarthy who started this subject9/15/2002 8:24:40 PM
From: John McCarthy   of 22
 
TARGETED GENE THERAPY

Subject:EB - GABEB
(The following material is presented in Ascending Date Order)

This post is generated by a program that reads a database and generates this file. Errors will result from incorrect database material. Updates to the database automatically reflected in this file.

Researcher Name shown is my estimate of Principal Researcher

DB Key:1999-EB-A
Doc:DEBRA International Current Research Projects
DEBRA International Current Research Projects
Vector:RDO RNA-DNA chimeric oligonucleotide
Experiment:Failed or Not Applicable
Of Note:TGF - Failed

10/1/1999-----Scheffer, H Dr-----University of Groningen, Netherlands
Title:Development of Gene Correction for Generalised Atrophic Benign Epidermolysis Bullosa (GABEB)
Link:http://www.debra-international.org/a_schyonk1.htm
2nd Link:http://www.debra-international.org/a_schyonk1a.htm
Disease Information:http://www.debra.org/about_eb.htm#WhatIsEB

DB Key:2000-EB-A
Doc:DEBRA International Current Research Projects
DEBRA International Current Research Projects >> Interim Report>>
Vector:RDO RNA-DNA chimeric oligonucleotide
Experiment:Failed or Not Applicable
Of Note:TGF - Failed

11/1/2000-----Rugg, Elizabeth L Dr-----St Bartholomews & the Royal London School of
Medicine & Dentistry
Title:Correction of Gene Defects in Epidermolysis Bullosa Simplex using Chimeric RNA/DNA Oligonucleotides
Link:http://www.debra-international.org/rugg1.htm
2nd Link:http://www.geneclinics.org/profiles/ebs/
Disease Information:http://www.debra.org/about_eb.htm#WhatIsEB

Snippet:
The construct (K19-X-GFP) is comprised of wild-type GFP placed in frame and downstream of cDNA encoding keratin 19 (K19) with its stop codon (TGA) intact.
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