United States Patent Application 20020142290
Kind Code A1
Powers, Jay P. ; et al. October 3, 2002
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NS5B HCV polymerase inhibitors
Abstract
Compounds, compositions and methods are provided that are useful in the treatment and prevention of certain viral infections and associated diseases. In particular, the compounds of the invention inhibit the activity of a viral RNA polymerase. The subject methods are particularly useful in the treatment of diseases causes by hepatitis C virus infection.
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Inventors: Powers, Jay P.; (Pacifica, CA) ; Jaen, Juan C.; (Burlingame, CA) ; Piper, Derek E.; (San Francisco, CA) ; Walker, Nigel P.C.; (Burlingame, CA) ; Li, Yang; (Mountain View, CA)
Correspondence Name and Address: TOWNSEND AND TOWNSEND AND CREW, LLP
TWO EMBARCADERO CENTER
EIGHTH FLOOR
SAN FRANCISCO
CA
94111-3834
US
Assignee Name and Adress: Tularik Inc.
South San Francisco
CA
Serial No.: 828270
Series Code: 09
Filed: April 5, 2001
U.S. Current Class: 435/5; 435/199; 562/426; 562/556
U.S. Class at Publication: 435/5; 435/199; 562/556; 562/426
Intern'l Class: C12Q 001/70; C12N 009/22; C07C 323/34; C07C 323/03
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Claims
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What is claimed is:
1. A compound that binds to a cysteine residue in the RNA-dependent RNA polymerase (RdRp) protein of a virus forming a covalent bond.
2. A compound of claim 1, wherein said RdRp protein is NS5B.
3. A compound of claim 1, wherein said virus is hepatitis C virus (HCV).
4. A compound of claim 1, wherein said cysteine residue corresponds to cysteine 366 in HCV NS5B.
5. A compound of claim 1, wherein said RdRp is NS5B and said virus is HCV.
6. A compound of claim 5, wherein said covalent bond is irreversible under physiological conditions.
7. A compound of claim 5, wherein said covalent bond is reversible under physiological conditions.
(snip, 55 claims total) |
